Ghrelin Gene Variants Influence on Metabolic Syndrome Components in Aged Spanish Population
Mora, Mireia (Hospital Clínic i Provincial de Barcelona)
Adam, Victoria (Hospital Clínic Universitari (València))
Palomera, Elisabet (Hospital de Mataró. Consorci Sanitari del Maresme)
Blesa, Sebastián (Hospital Clínic Universitari (València))
Díaz-Soto, Gonzalo (Hospital Clínico Universitario de Valladolid)
Buquet, Xavier (Hospital de Mataró. Consorci Sanitari del Maresme)
Serra-Prat, Mateu (Hospital de Mataró. Consorci Sanitari del Maresme)
Martín-Escudero, Juan Carlos (Hospital Universitario Río Hortega (Valladolid))
Palanca, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Chaves, Javier Felipe (Hospital Clínic Universitari (València))
Puig Domingo, Manuel (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Mataró Aging Study Group

Data:	2015
Resum:	BACKGROUND: The role of genetic variations within the ghrelin gene on cardiometabolic profile and nutritional status is still not clear in humans, particularly in elderly people. OBJECTIVES: We investigated six SNPs of the ghrelin gene and their relationship with metabolic syndrome (MS) components. SUBJECTS AND METHODS: 824 subjects (413 men/411 women, age 77. 31±5. 04) participating in the Mataró aging study (n = 310) and the Hortega study (n = 514) were analyzed. Anthropometric variables, ghrelin, lipids, glucose and blood pressure levels were measured, and distribution of SNPs -994CT (rs26312), -604GA (rs27647), -501AC (rs26802), R51Q (rs34911341), M72L (rs696217) and L90G (rs4684677) of the ghrelin gene evaluated. Genotypes were determined by multiplex PCR and SNaPshot minisequencing. MS (IDF criteria) was found in 54. 9%. RESULTS:No association between any of the SNPs and levels of total fasting circulating ghrelin levels was found. C/A-A/A genotype of M72L was associated with increased risk of central obesity according to IDF criteria, while G/A-G/G genotypes of -604GA with reduced risk. A/A genotype of -501AC polymorphism was associated to decreased BMI. In relation to lipid profile, the same genotypes of -604GA were associated with increased total cholesterol and LDL-cholesterol and -501AC with reduced triglycerides. There were no associations with systolic or diastolic blood pressure levels or with hypertension, glucose levels or diabetes and ghrelin polymorphisms. However, G/G genotype of -604GA was associated with glucose.
Ajuts:	Instituto de Salud Carlos III PROMETEO/2009/029
Nota:	Altres ajuts: Fondo Investigaciones Sanitarias Grants 07/0601 And PI11/00726, by CIBER de Diabetes y Enfermedades Metabólicas Relacionadas (CIBERDEM); CIBERDEM is an initiative by Carlos III Health Institute in Madrid and the Spanish Health Ministry, by PROMETEO/2009/029, AP-091/11, and ACOMP/2013/039 from the Valencian Government.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Síndrome metabòlica ; Ghrelin gene ; Aged population
Publicat a:	PloS one, Vol. 10 Núm. 9 (september 2015) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0136931
PMID: 26375586

17 p, 249.1 KB

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