Taxane-Induced Peripheral Neurotoxicity
Velasco Fargas, Roser (Hospital Universitari de Bellvitge)
Bruna, Jordi ![ORCID Identifier](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Institut de Neurociències)
Date: |
2015 |
Abstract: |
Taxane-derived agents are chemotherapy drugs widely employed in cancer treatment. Among them, paclitaxel and docetaxel are most commonly administered, but newer formulations are being investigated. Taxane antineoplastic activity is mainly based on the ability of the drugs to promote microtubule assembly, leading to mitotic arrest and apoptosis in cancer cells. Peripheral neurotoxicity is the major non-hematological adverse effect of taxane, often manifested as painful neuropathy experienced during treatment, and it is sometimes irreversible. Unfortunately, taxane-induced neurotoxicity is an uncertainty prior to the initiation of treatment. The present review aims to dissect current knowledge on real incidence, underlying pathophysiology, clinical features and predisposing factors related with the development of taxane-induced neuropathy. |
Rights: |
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Language: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Subject: |
Taxane ;
Paclitaxel ;
Docetaxel ;
Nab-paclitaxel ;
Cabazitaxel ;
Chemotherapy-induced peripheral neuropathy ;
Neurotoxicity ;
Peripheral neuropathy ;
Taxane-induced peripheral neuropathy |
Published in: |
Toxics, Vol. 3 Núm. 2 (April 2015) , p. 152-169, ISSN 2305-6304 |
DOI: 10.3390/toxics3020152
PMID: 29056655
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Record created 2016-12-09, last modified 2024-06-01