Taxane-Induced Peripheral Neurotoxicity
Velasco Fargas, Roser (Hospital Universitari de Bellvitge)
Bruna, Jordi (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date:	2015
Abstract:	Taxane-derived agents are chemotherapy drugs widely employed in cancer treatment. Among them, paclitaxel and docetaxel are most commonly administered, but newer formulations are being investigated. Taxane antineoplastic activity is mainly based on the ability of the drugs to promote microtubule assembly, leading to mitotic arrest and apoptosis in cancer cells. Peripheral neurotoxicity is the major non-hematological adverse effect of taxane, often manifested as painful neuropathy experienced during treatment, and it is sometimes irreversible. Unfortunately, taxane-induced neurotoxicity is an uncertainty prior to the initiation of treatment. The present review aims to dissect current knowledge on real incidence, underlying pathophysiology, clinical features and predisposing factors related with the development of taxane-induced neuropathy.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Taxane ; Paclitaxel ; Docetaxel ; Nab-paclitaxel ; Cabazitaxel ; Chemotherapy-induced peripheral neuropathy ; Neurotoxicity ; Peripheral neuropathy ; Taxane-induced peripheral neuropathy
Published in:	Toxics, Vol. 3 Núm. 2 (April 2015) , p. 152-169, ISSN 2305-6304

DOI: 10.3390/toxics3020152
PMID: 29056655

18 p, 205.0 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles