Intracranial self-stimulation also facilitates learning in a visual discrimination task in the Morris water maze in rats
García-Brito, Soleil (Universitat Autònoma de Barcelona. Institut de Neurociències)
Morgado-Bernal, Ignacio (Universitat Autònoma de Barcelona. Institut de Neurociències)
Biosca Simón, Neus (Universitat Autònoma de Barcelona. Institut de Neurociències)
Segura Torres, Pilar (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date:	2017
Abstract:	Intracranial self-Stimulation (ICSS) of the medial forebrain bundle is a treatment capable of consistently facilitating acquisition of learning and memory in a wide array of experimental paradigms in rats. However, the evidence supporting this effect on implicit memory comes mainly from classical conditioning and avoidance tasks. The present work aims to determine whether ICSS would also improve the performance of rats in another type of implicit task such as cued simultaneous visual discrimination in the Morris Water Maze. The ICSS treatment was administered immediately after each of the five acquisition sessions and its effects on retention and reversal were evaluated 72h later. Results showed that ICSS subjects committed fewer errors than Sham subjects and adopted more accurate trajectories during the acquisition of the task. This improvement was maintained until the probe test at 72h. However, ICSS animals experienced more difficulties than the Sham group during the reversal of the same learning, reflecting an impairment in cognitive flexibility. We conclude that post-training ICSS could also be an effective treatment for improving implicit visual discrimination learning and memory.
Grants:	Ministerio de Ciencia e Innovación PSI2013-41018-P Ministerio de Economía y Competitividad BES-2014-068393
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Deep brain stimulation ; Intracranial self-stimulation ; Medial forebrain bundle ; Memory enhancement ; Morris water maze ; Simultaneous visual discrimination
Published in:	Behavioural Brain Research, Vol. 317 (January 2017) , p. 360-366, ISSN 1872-7549

DOI: 10.1016/j.bbr.2016.09.069

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