Web of Science: 13 citations, Scopus: 14 citations, Google Scholar: citations,
Nanostructured recombinant cytokines : A highly stable alternative to short-lived prophylactics
Torrealba, Debora (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Parra, David (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia Animal i Immunologia)
Seras Franzoso, Joaquin (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Vallejos Vidal, Eva Carolina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Yero Corona, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Gibert, Isidre (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Villaverde, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
García Fruitós, Elena (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Departament de Biologia, de Fisiologia i d'Immunologia)

Date: 2016
Abstract: Cytokines have been widely used as adjuvants and therapeutic agents in treatments of human diseases. Despite their recognized potential as drugs, the medical use of cytokines has considerable drawbacks, mainly related to their low stability and short half-life. Such intrinsic limitations imply the administration of high doses, often prompting toxicity, undesirable side effects and greater production costs. Here, we describe a new category of mechanically stable nanostructured cytokines (TNFα and CCL4/MIP-1β) that resist harsh physicochemical conditions in vitro (pH and temperature), while maintaining functionality. These bio-functional materials are produced in recombinant cell factories through cost-effective and fully scalable processes. Notably, we demonstrate their prophylactic potential in vivo showing they protect zebrafish from a lethal infection by Pseudomonas aeruginosa.
Note: info:eu-repo/MINECO/AGL2012-33877
Note: info:eu-repo/MINECO/AGL2015-65129-R
Note: info:eu-repo/MINECO/RTA2012-00028-C02-02
Note: info:eu-repo/AGAUR/2014/SGR-345
Note: info:eu-repo/AGAUR/2014/SGR-132
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Language: Anglès.
Document: article ; recerca ; acceptedVersion
Published in: Biomaterials, Vol. 107 (Novembre 2016) , p. 102-114, ISSN 0142-9612

DOI: 10.1016/j.biomaterials.2016.08.043


Post-print
33 p, 4.2 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2017-05-04, last modified 2019-02-19



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