Impact of Obstructive Sleep Apnea on the Levels of Placental Growth Factor (PlGF) and Their Value for Predicting Short-Term Adverse Outcomes in Patients with Acute Coronary Syndrome
Barcelo Bennasar, Antonia (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Bauça, Josep Miquel (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Yáñez, Aina M (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Fueyo, Laura (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Gomez, Cristina (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
De la Peña, Mónica (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Pierola, Javier (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Rodriguez, Alberto (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Sánchez-de-la-Torre, Manuel (Hospital Universitari Arnau de Vilanova and Santa Maria)
Abad Capa, Jorge (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mediano, Olga (Hospital Universitario de Guadalajara)
Amilibia, Jose (Hospital Universitario de Cruces (Barakaldo, País Basc))
Masdeu, María José (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Teran, Joaquin (Hospital General Yagüe (Burgos))
Montserrat Canal, José Ma (Hospital Clínic i Provincial de Barcelona)
Mayos, Mercè (Institut d'Investigació Biomèdica Sant Pau)
Sanchez-De-La-Torre, Alicia (Hospital Universitari Arnau de Vilanova and Santa Maria)
Barbé, Ferran (Hospital Universitari Arnau de Vilanova and Santa Maria)

Date:	2016
Abstract:	BACKGROUND: Placental growth factor (PlGF) induces angiogenesis and promotes tissue repair, and plasma PlGF levels change markedly during acute myocardial infarction (AMI). Currently, the impact of obstructive sleep apnea (OSA) in patients with AMI is a subject of debate. Our objective was to evaluate the relationships between PlGF levels and both the severity of acute coronary syndrome (ACS) and short-term outcomes after ACS in patients with and without OSA. METHODS: A total of 538 consecutive patients (312 OSA patients and 226 controls) admitted for ACS were included in this study. All patients underwent polygraphy in the first 72 hours after hospital admission. The severity of disease and short-term prognoses were evaluated during the hospitalization period. Plasma PlGF levels were measured using an electrochemiluminescence immunoassay. RESULTS: Patients with OSA were significantly older and more frequently hypertensive and had higher BMIs than those without OSA. After adjusting for age, smoking status, BMI and hypertension, PlGF levels were significantly elevated in patients with OSA compared with patients without OSA (19. 9 pg/mL, interquartile range: 16. 6-24. 5 pg/mL; 18. 5 pg/mL, interquartile range: 14. 7-22. 7 pg/mL; p<0. 001), and a higher apnea-hypopnea index (AHI) was associated with higher PlGF concentrations (p<0. 003). Patients with higher levels of PlGF had also an increased odds ratio for the presence of 3 or more diseased vessels and for a Killip score.
Grants:	Instituto de Salud Carlos III FIS/PI10/02763 Instituto de Salud Carlos III FIS/PI10/02745
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 11 Núm. 3 (March 2016) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0147686
PMID: 26930634

12 p, 237.9 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles