Web of Science: 36 citations, Scopus: 36 citations, Google Scholar: citations,
Genome-wide DNA copy number analysis of acute lymphoblastic leukemia identifies new genetic markers associated with clinical outcome
Forero Castro, Maribel (Instituto de Investigación Biomédica de Salamanca)
Robledo, Cristina (Instituto de Investigación Biomédica de Salamanca)
Benito, Rocío (Instituto de Investigación Biomédica de Salamanca)
Abáigar, María (Instituto de Investigación Biomédica de Salamanca)
África Martín, Ana (Instituto de Investigación Biomédica de Salamanca)
Arefi, Maryam (Hospital Clínico Universitario de Valladolid)
Fuster, José Luis (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Heras, Natalia de las (Hospital Universitario de León)
Rodríguez, Juan N. (Hospital Juan Ramón Jiménez (Huelva))
Quintero, Jonathan (Hospital Universitario Miguel Servet (Saragossa))
Riesco, Susana (Hospital Universitario de Salamanca)
Hermosín, Lourdes (Hospital Universitario de Jerez (Jerez de la Frontera))
Fuente, Ignacio de la (Hospital Universitario Río Hortega (Valladolid))
Recio, Isabel (Hospital Nuestra Señora de Sonsoles (Àvila))
Ribera Salas, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Labrador, Jorge (Hospital Universitario de Burgos)
Alonso, José M. (Hospital Río Carrión (Palència))
Olivier, Carmen (Hospital General de Segovia)
Sierra, Magdalena (Hospital Virgen de la Concha (Zamora))
Megido, Marta (Hospital del Bierzo (Ponferrada, Lleó))
Corchete Sánchez, Luis Antonio (Hospital Universitario de Salamanca)
Ciudad Pizarro, Juana (Hospital Universitario de Salamanca)
García, Juan Luis (Instituto de Estudios de Ciencias de la Salud de Castilla y León)
Ribera, Jose-Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Hernández Rivas, Jesús María (Hospital Universitario de Salamanca)

Date: 2016
Abstract: Identifying additional genetic alterations associated with poor prognosis in acute lymphoblastic leukemia (ALL) is still a challenge. Aims: To characterize the presence of additional DNA copy number alterations (CNAs) in children and adults with ALL by whole-genome oligonucleotide array (aCGH) analysis, and to identify their associations with clinical features and outcome. Array-CGH was carried out in 265 newly diagnosed ALLs (142 children and 123 adults). The NimbleGen CGH 12x135K array (Roche) was used to analyze genetic gains and losses. CNAs were analyzed with GISTIC and aCGHweb software. Clinical and biological variables were analyzed. Three of the patients showed chromothripsis (cth6, cth14q and cth15q). CNAs were associated with age, phenotype, genetic subtype and overall survival (OS). In the whole cohort of children, the losses on 14q32. 33 (p = 0. 019) and 15q13. 2 (p = 0. 04) were related to shorter OS. In the group of children without good- or poor-risk cytogenetics, the gain on 1p36. 11 was a prognostic marker independently associated with shorter OS. In adults, the gains on 19q13. 2 (p = 0. 001) and Xp21. 1 (p = 0. 029), and the loss of 17p (p = 0. 014) were independent markers of poor prognosis with respect to OS. In summary, CNAs are frequent in ALL and are associated with clinical parameters and survival. Genome-wide DNA copy number analysis allows the identification of genetic markers that predict clinical outcome, suggesting that detection of these genetic lesions will be useful in the management of patients newly diagnosed with ALL.
Grants: European Commission 306242
Ministerio de Economía y Competitividad PI12/00281
Note: Altres ajuts: FUCALHH 2013; HUS272U13; GRS 994/A/14, BIO/SA10/14, BIO/SA31/13; Fundación Española de Hematología y Hemoterapia (FEHH), Universidad Pedagógica y Tecnológica de Colombia 223-2011
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: Article ; recerca ; Versió publicada
Subject: Genome-wide DNA copy number ; Acute lymphoblastic leukemia ; Leucèmia linfoblàstica aguda
Published in: PloS one, Vol. 11 Núm. 2 (February 2016) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0148972
PMID: 26872047


20 p, 1.4 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles

 Record created 2017-05-22, last modified 2023-03-28



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