Adhesion Molecules Associated with Female Genital Tract Infection
Qualai, Jamal (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Cantero, Jon (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Li, Lin Xi (University of Arkansas for Medical Sciences)
Carrascosa, José Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cabré i Gelada, Eduard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Dern, Olga (Institut Català de la Salut. Centre d'Atenció Primària Sant Fèlix)
Sumoy, Lauro (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
Requena, Gerard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
McSorley, Stephen J. (University of California. Center for Comparative Medicine)
Genescà Ferrer, Meritxell (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)

Date:	2016
Abstract:	Efforts to develop vaccines that can elicit mucosal immune responses in the female genital tract against sexually transmitted infections have been hampered by an inability to measure immune responses in these tissues. The differential expression of adhesion molecules is known to confer site-dependent homing of circulating effector T cells to mucosal tissues. Specific homing molecules have been defined that can be measured in blood as surrogate markers of local immunity (e. g. α4β7 for gut). Here we analyzed the expression pattern of adhesion molecules by circulating effector T cells following mucosal infection of the female genital tract in mice and during a symptomatic episode of vaginosis in women. While CCR2, CCR5, CXCR6 and CD11c were preferentially expressed in a mouse model of Chlamydia infection, only CCR5 and CD11c were clearly expressed by effector T cells during bacterial vaginosis in women. Other homing molecules previously suggested as required for homing to the genital mucosa such as α4β1 and α4β7 were also differentially expressed in these patients. However, CD11c expression, an integrin chain rarely analyzed in the context of T cell immunity, was the most consistently elevated in all activated effector CD8+ T cell subsets analyzed. This molecule was also induced after systemic infection in mice, suggesting that CD11c is not exclusive of genital tract infection. Still, its increase in response to genital tract disorders may represent a novel surrogate marker of mucosal immunity in women, and warrants further exploration for diagnostic and therapeutic purposes.
Grants:	Instituto de Salud Carlos III PI14/01235
Note:	Altres ajuts: Marie Curie Career Integration Grant i una beca Fundació Dexeus Salut de la Dona
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Malalties venèries ; Female genital tract ; Sexually transmitted infections
Published in:	PloS one, Vol. 11 Núm. 6 (Juny 2016) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0156605
PMID: 27272720

21 p, 3.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles