The elongator complex regulates hypocotyl growth in darkness and during photomorphogenesis
Woloszynska, Magdalena (Universiteit Gent. Vakgroep Plantenbiotechnologie en Bio-informatica)
Gagliardi, Olimpia (Universiteit Gent. Vakgroep Plantenbiotechnologie en Bio-informatica)
Vandenbussche, Filip (Universiteit Gent. Vakgroep Fysiologie)
De Groeve, Steven (Universiteit Gent. Vakgroep Plantenbiotechnologie en Bio-informatica)
Alonso Baez, Luis (Universiteit Gent. Vakgroep Plantenbiotechnologie en Bio-informatica)
Neyt, Pia (Universiteit Gent. Vakgroep Plantenbiotechnologie en Bio-informatica)
Le Gall, Sabine (Universiteit Gent. Vakgroep Plantenbiotechnologie en Bio-informatica)
Fung Uceda, Jorge Alberto (Centre de Recerca en Agrigenòmica)
Mas, Paloma (Centre de Recerca en Agrigenòmica)
Van Der Straeten, Dominique (Universiteit Gent. Vakgroep Fysiologie)
Van Lijsebettens, Mieke (Universiteit Gent. Vakgroep Plantenbiotechnologie en Bio-informatica)

Data:	2018
Resum:	Elongator promotes RNA polymerase II-mediated transcript elongation through epigenetic activities such as histone acetylation. Elongator regulates growth, development, immune response, sensitivity to drought and abscisic acid. We demonstrate that elo mutants exhibit defective hypocotyl elongation but have a normal apical hook in darkness and are hyposensitive to light during photomorphogenesis. These elo phenotypes are supported by transcriptome changes, i. e. downregulation of circadian clock components, positive regulators of skoto- or photomorphogenesis, hormonal pathways and cell wall biogenesis-related factors. The downregulated genes LHY, HFR1 and HYH are selectively targeted by Elongator for histone H3K14 acetylation in darkness. The role of Elongator in early seedling development in darkness and light is supported by hypocotyl phenotypes of mutants defective in components of the gene network regulated by Elongator, and double mutants between elo and mutants in light or darkness signaling components. A model is proposed in which Elongator represses the plant immune response and promotes hypocotyl elongation and photomorphogenesis via transcriptional control of positive photomorphogenesis regulators and a growth-regulatory network that converges on genes involved in cell wall biogenesis and hormone signaling.
Ajuts:	European Commission 273068 European Commission 607880
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Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Journal of cell science, Vol. 131 (2018) art. jcs203927, ISSN 0021-9533

DOI: 10.1242/jcs.203927
PMID: 28720596

12 p, 2.2 MB

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