Differences in phagocytosis susceptibility in Haemophilus parasuis strains
Olvera, Alexandre (Fundació Centre de Recerca en Sanitat Animal)
Ballester, Maria (Fundació Centre de Recerca en Sanitat Animal)
Nofrarías, Miquel (Fundació Centre de Recerca en Sanitat Animal)
Sibila, Marina (Fundació Centre de Recerca en Sanitat Animal)
Aragon, Virginia

Date: 2009
Abstract: Haemophilus parasuis is a colonizer of the upper respiratory tract of healthy pigs, but virulent strains can cause a systemic infection characterized by fibrinous polyserositis, commonly known as Glässer's disease. The variability in virulence that is observed among H. parasuis strains is not completely understood, since the virulence mechanisms of H. parasuis are largely unknown. In the course of infection, H. parasuis has to survive the host pulmonary defences, which include alveolar macrophages, to produce disease. Using strains from different clinical backgrounds, we were able to detect clear differences in susceptibility to phagocytosis. Strains isolated from the nose of healthy animals were efficiently phagocytosed by porcine alveolar macrophages (PAM), while strains isolated from systemic lesions were resistant to this interaction. Phagocytosis of susceptible strains proceeded through mechanisms independent of a specific receptor, which involved actin filaments and microtubules. In all the systemic strains tested in this study, we observed a distinct capsule after interaction with PAM, indicating a role of this surface structure in phagocytosis resistance. However, additional mechanisms of resistance to phagocytosis should be explored, since we detected different effects of microtubule inhibition among systemic strains.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre i quan aquestes es distribueixin sota la mateixa llicència que regula l'obra original i es reconegui l'autoria. Creative Commons
Language: Anglès.
Document: review ; ressenya ; publishedVersion ; article
Published in: Veterinary Research, Vol. 40 (2 2009) , ISSN 1297-9716

PMID: 19239855


12 p, 1.8 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Centre de Recerca en Sanitat Animal (CReSA-IRTA)
Articles > Published articles
Articles > Reviews

 Record created 2017-12-20, last modified 2019-05-06



   Favorit i Compartir