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Página principal > Artículos > Artículos publicados > Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice |
Fecha: | 2010 |
Resumen: | The 3xTg-AD mouse develops a progressive Alzheimer's disease- (AD-) like brain pathology that causes cognitive- and neuropsychiatric-like symptoms of dementia. Since its neuroimmunoendocrine axis is likewise impaired, this mouse is also useful for modelling complex age-related neurodegeneration. This study analyzed behavioral, physiological, neurochemical, pathological and immunoendocrine alterations in male and female 3xTg-AD mice and assayed the effects of a short therapy of forced physical exercise at the moderate pathology stage of 6 months of age. Gender effects were observed in most AD-related pathology and dysfunctions. Five weeks of treadmill training produced beneficial effects, such as the reduction of brain oxidative stress and GABA-A receptor dysfunction in males and improvement of sensorimotor function in females. In both sexes, exercise decreased the brain amyloid β 42/40 ratio levels. The results highlight the importance of analyzing experimental therapies in both mouse model genders in order to improve our understanding of the disease and develop more appropriate therapies. |
Ayudas: | Instituto de Salud Carlos III RD06/0013-0003 Instituto de Salud Carlos III RD06-0013-1004 Ministerio de Ciencia e Innovación SAF2006-13642 Ministerio de Ciencia e Innovación SAF2009-13093-C02-02 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Publicado en: | International Journal of Alzheimer's Disease, Vol. 2010 (10 2010) , ISSN 2090-0252 |
17 p, 2.1 MB |