Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)
García, Yoelvis (Institut d'Investigació Biomèdica Sant Pau)
Buccieri, Karla (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Revilla, Susana (Institut d'Investigació Biomèdica Sant Pau)
Suñol, Cristina (Institut d'Investigació Biomèdica Sant Pau)
Cristofol, Rosa (Institut d'Investigació Biomèdica Sant Pau)
Sanfeliu i Pujol, Coral (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2010
Abstract:	The 3xTg-AD mouse develops a progressive Alzheimer's disease- (AD-) like brain pathology that causes cognitive- and neuropsychiatric-like symptoms of dementia. Since its neuroimmunoendocrine axis is likewise impaired, this mouse is also useful for modelling complex age-related neurodegeneration. This study analyzed behavioral, physiological, neurochemical, pathological and immunoendocrine alterations in male and female 3xTg-AD mice and assayed the effects of a short therapy of forced physical exercise at the moderate pathology stage of 6 months of age. Gender effects were observed in most AD-related pathology and dysfunctions. Five weeks of treadmill training produced beneficial effects, such as the reduction of brain oxidative stress and GABA-A receptor dysfunction in males and improvement of sensorimotor function in females. In both sexes, exercise decreased the brain amyloid β 42/40 ratio levels. The results highlight the importance of analyzing experimental therapies in both mouse model genders in order to improve our understanding of the disease and develop more appropriate therapies.
Grants:	Instituto de Salud Carlos III RD06/0013-0003 Instituto de Salud Carlos III RD06-0013-1004 Ministerio de Ciencia e Innovación SAF2006-13642 Ministerio de Ciencia e Innovación SAF2009-13093-C02-02
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	International Journal of Alzheimer's Disease, Vol. 2010 (10 2010) , ISSN 2090-0252

DOI: 10.4061/2010/128354
PMID: 20981262

17 p, 2.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles