Copper Modulation as a Therapy for Alzheimer's Disease?
Manso Sanz, Yasmina (Universitat Autònoma de Barcelona. Institut de Neurociències)
Comes, Gemma (Universitat Autònoma de Barcelona. Institut de Neurociències)
Hidalgo Pareja, Juan (Universitat Autònoma de Barcelona. Institut de Neurociències)
Bush, Ashley I. (The Mental Health Research Institute. Oxidation Biology Laboratory (Australia))
Adlard, Paul A. (The University of Melbourne. Department of Pathology (Australia))
Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia

Date:	2011
Abstract:	The role of metals in the pathophysiology of Alzheimer's disease (AD) has gained considerable support in recent years, with both in vitro and in vivo data demonstrating that a mis-metabolism of metal ions, such as copper and zinc, may affect various cellular cascades that ultimately leads to the development and/or potentiation of AD. In this paper, we will provide an overview of the preclinical and clinical literature that specifically relates to attempts to affect the AD cascade by the modulation of brain copper levels. We will also detail our own novel animal data, where we treated APP/PS1 (7-8 months old) mice with either high copper (20 ppm in the drinking water), high cholesterol (2% supplement in the food) or a combination of both and then assessed β -amyloid (A β ) burden (soluble and insoluble A β ), APP levels and behavioural performance in the Morris water maze. These data support an interaction between copper/cholesterol and both A β and APP and further highlight the potential role of metal ion dyshomeostasis in AD.
Grants:	Ministerio de Educación y Ciencia SAF2005-00671 Ministerio de Educación y Ciencia SAF2008-00435 Ministerio de Educación y Ciencia AP2005-0588
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	International Journal of Alzheimer's Disease, Vol. 2011 (June 2011) , art. 370345, ISSN 2090-0252

DOI: 10.4061/2011/370345
PMID: 21876828

5 p, 722.3 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
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Articles > Published articles