Stem Cell Therapy : A New Treatment for Burns?
Arno, Anna (Hospital Universitari Vall d'Hebron)
Smith, Alexandra H. (University of Toronto. Sunnybrook Health Sciences Centre)
Blit, Patrick H. (University of Toronto. Sunnybrook Health Sciences Centre)
Shehab, Mohammed Al (University of Toronto. Sunnybrook Health Sciences Centre)
Gauglitz, Gerd G. (Department of Dermatology and Allergology, Ludwig Maximilians University, Geschwister-Scholl-Platz 1, 80539, Munich, Germany)
Jeschke, Marc G. (University of Toronto. Sunnybrook Health Sciences Centre)
Universitat Autònoma de Barcelona

Data:	2011
Resum:	Stem cell therapy has emerged as a promising new approach in almost every medicine specialty. This vast, heterogeneous family of cells are now both naturally (embryonic and adult stem cells) or artificially obtained (induced pluripotent stem cells or iPSCs) and their fates have become increasingly controllable, thanks to ongoing research in this passionate new field. We are at the beginning of a new era in medicine, with multiple applications for stem cell therapy, not only as a monotherapy, but also as an adjunct to other strategies, such as organ transplantation or standard drug treatment. Regrettably, serious preclinical concerns remain and differentiation, cell fusion, senescence and signalling crosstalk with growth factors and biomaterials are still challenges for this promising multidisciplinary therapeutic modality. Severe burns have several indications for stem cell therapy, including enhancement of wound healing, replacement of damaged skin and perfect skin regeneration - incorporating skin appendages and reduced fibrosis -, as well as systemic effects, such as inflammation, hypermetabolism and immunosuppression. The aim of this review is to describe well established characteristics of stem cells and to delineate new advances in the stem cell field, in the context of burn injury and wound healing.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Stem cells ; Burn ; Tissue engineering ; Regenerative medicine
Publicat a:	Pharmaceuticals, Vol. 4 (october 2011) , p. 1355-1380, ISSN 1424-8247

DOI: 10.3390/ph4101355
PMID: 27721328

26 p, 542.7 KB

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