The Association of Hypovitaminosis D with the Metabolic Syndrome Is Independent of the Degree of Obesity
Miñambres, Inka (Institut d'Investigació Biomèdica Sant Pau)
Sánchez-Hernández, Joan (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas)
Sanchez-Quesada, Jose Luis (Institut d'Investigació Biomèdica Sant Pau)
Rodríguez, Jose (Institut d'Investigació Biomèdica Sant Pau)
Leiva Hidalgo, Alberto de, (Universitat Autònoma de Barcelona. Departament de Medicina)
Pérez Pérez, Antonio (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2012
Abstract:	Background. It remains uncertain whether the metabolic syndrome (MS) or insulin resistance contribute to the association between vitamin D deficiency and obesity. Methods. We conducted a cross-sectional survey of 343 subjects who were overweight or obese. We analyzed anthropometric data and the presence or absence of MS. Additionally, we determined 25-hydroxyvitamin D (25OHD) and insulin concentrations, and the HOMA index was calculated. Chi-square test,Mann-Whitney U test, Student's t -tests,and logistic regression analysis were used. Results. The mean age of the patients was 42 ± 11 years, and 65. 9% were women. The mean BMI was 34. 7 ± 8. 3 kg/m 2 and 25(OH)D levels were 53. 7 ± 29. 8 nmol/L. Forty-six patients (13. 4%) had MS. Vitamin D status was associated with the degree of obesity, especially with a BMI > 40 kg/m 2. Patients with MS had lower levels of 25(OH)D than patients without (43. 3 ± 29. 0 versus 55. 3 ± 29. 6 mmol/L, resp. ), and the odds ratio for hypovitaminosis D was 2. 7 (confidence interval (CI), 1. 14-6. 4) (P =. 023) for patients with MS versus patients without MS, irrespective of the degree of obesity. Conclusions. Our data confirm the association between vitamin D and MS and suggest that this association is independent of the degree of obesity.
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Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	ISRN Endocrinology, Vol. 2012 (october 2012) , ISSN 2090-4649

DOI: 10.5402/2012/691803
PMID: 23150833

5 p, 474.0 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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