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Regulatory T cells modulate inflammation and reduce infarct volume in experimental brain ischaemia
Brea, David (Institut Germans Trias i Pujol)
Agulla, Jesús (Instituto de Investigación Biomédica de Salamanca, Hospital Universitario de Salamanca)
Rodríguez-Yáñez, Manuel (Instituto de Investigacións Sanitarias de Santiago)
Barral, David (Instituto de Investigacións Sanitarias de Santiago)
Ramos-Cabrer, Pedro (Instituto de Investigacións Sanitarias de Santiago)
Campos, Francisco (Instituto de Investigacións Sanitarias de Santiago)
Almeida, Angeles (Instituto de Investigación Biomédica de Salamanca, Hospital Universitario de Salamanca)
Dávalos, Antoni (Institut Germans Trias i Pujol)
Castillo, José (Instituto de Investigacións Sanitarias de Santiago)
Universitat Autònoma de Barcelona

Date: 2014
Abstract: Brain ischaemia (stroke) triggers an intense inflammatory response predominately mediated by the accumulation of inflammatory cells and mediators in the ischaemic brain. In this context, regulatory T (Treg) cells, a subpopulation of CD4 + T cells with immunosuppressive and anti-inflammatory properties, are activated in the late stages of the disease. To date, the potential therapeutic usefulness of Treg cells has not been tested. In this study, we aimed to investigate whether Treg cells exert protection/repair following stroke. Both the adoptive transfer of Treg cells into ischaemic rats and the stimulation of endogenous T-cell proliferation using a CD28 superagonist reduced the infarct size at 3-28 days following the ischaemic insult. Moreover, T cell-treated animals had higher levels of FoxP3 and lower levels of IL-1β, CD11b+ and CD68+ cells in the infarcted hemisphere when compared with control animals. However, T-cell treatment did not alter the rate of proliferation of NeuN-, NCAM- or CD31-positive cells, thereby ruling out neurogenesis and angiogenesis in protection. These results suggest that adoptive transfer of T cells is a promising therapeutic strategy against the neurological consequences of stroke.
Note: Número d'acord de subvenció ISCIII/PI11/02636
Note: Número d'acord de subvenció ISCIII/RETICS-INVICTUS/R012/0014
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Cerebrovascular disease/stroke ; Regulatory T cells ; Inflammation ; Immunomodulation
Published in: Journal of Cellular and Molecular Medicine, Vol. 18 (may 2014) , p. 1571-1579, ISSN 1582-4934

PMID: 24889329
DOI: 10.1111/jcmm.12304

9 p, 2.0 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles

 Record created 2018-01-29, last modified 2020-02-08

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