Web of Science: 19 cites, Scopus: 17 cites, Google Scholar: cites,
Recent Positive Selection Has Acted on Genes Encoding Proteins with More Interactions within the Whole Human Interactome
Luisi, Pierre (Universitat Pompeu Fabra-CSIC. Institute of Evolutionary Biology)
Alvarez-Ponce, David (Universitat Pompeu Fabra-CSIC. Institute of Evolutionary Biology)
Pybus, Marc (Universitat Pompeu Fabra-CSIC. Institute of Evolutionary Biology)
Fares, Mario A. (University of Dublin. Smurfit Institute of Genetics)
Bertranpetit, Jaume (Universitat Pompeu Fabra-CSIC. Institute of Evolutionary Biology)
Laayouni, Hafid (Universitat Autonòma de Barcelona. Departament de Genètica i de Microbiologia)

Data: 2015
Resum: Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying more important positions than others and thus being likely to be under stronger selective pressures. However, how positive selection distributes across the different parts of molecular networks is still not fully understood. Here, we inferred positive selection using comparative genomics and population genetics approaches through the comparison of 10 mammalian and 270 human genomes, respectively. In agreement with previous results, we found that genes with lower network centralities are more likely to evolve under positive selection (as inferred from divergence data). Surprisingly, polymorphism data yield results in the opposite direction than divergence data: Genes with higher centralities are more likely to have been targeted by recent positive selection during recent human evolution. Our results indicate that the relationship between centrality and the impact of adaptive evolution highly depends on the mode of positive selection and/or the evolutionary time-scale.
Nota: Número d'acord de subvenció MINECO/BFU2013-43726-P
Nota: Número d'acord de subvenció AGAUR/2009/SGR-1101
Nota: Número d'acord de subvenció MINECO/JCI-2011-11089
Nota: Número d'acord de subvenció MINECO/BFU2012-36346
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Matèria: Physical protein interaction ; Protein interaction network ; Natural selection ; Positive selection ; Mammals ; Humans
Publicat a: Genome Biology and Evolution, Vol. 7, issue 4 (april 2015) , p. 1141-1154, ISSN 1759-6653

PMID: 25840415
DOI: 10.1093/gbe/evv055


14 p, 654.2 KB

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