Causes of non-adherence to therapeutic guidelines in severe community-acquired pneumonia
Gattarello, Simone (Hospital Universitari Vall d'Hebron)
Ramírez, Sergio (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Almarales, José Rafael (Universidad Tecnológica de Pereira)
Borgatta, Barbara (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Lagunes, Leonel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Encina, Belén (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Rello, Jordi (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Universitat Autònoma de Barcelona

Data:	2015
Resum:	To assess the adherence to Infectious Disease Society of America/American Thoracic Society guidelines and the causes of lack of adherence during empirical antibiotic prescription in severe pneumonia in Latin America. A clinical questionnaire was submitted to 36 physicians from Latin America; they were asked to indicate the empirical treatment in two fictitious cases of severe respiratory infection: community-acquired pneumonia and nosocomial pneumonia. In the case of communityacquired pneumonia, 11 prescriptions of 36 (30. 6%) were compliant with international guidelines. The causes for non-compliant treatment were monotherapy (16. 0%), the unnecessary prescription of broad-spectrum antibiotics (40. 0%) and the use of non-recommended antibiotics (44. 0%). In the case of nosocomial pneumonia, the rate of adherence to the Infectious Disease Society of America/American Thoracic Society guidelines was 2. 8% (1 patient of 36). The reasons for lack of compliance were monotherapy (14. 3%) and a lack of dual antibiotic coverage against Pseudomonas aeruginosa (85. 7%). If monotherapy with an antipseudomonal antibiotic was considered adequate, the antibiotic treatment would be adequate in 100% of the total prescriptions. The compliance rate with the Infectious Disease Society of America/American Thoracic Society guidelines in the community-acquired pneumonia scenario was 30. 6%; the most frequent cause of lack of compliance was the indication of monotherapy. In the case of nosocomial pneumonia, the compliance rate with the guidelines was 2. 8%, and the most important cause of non-adherence was lack of combined antipseudomonal therapy. If the use of monotherapy with an antipseudomonal antibiotic was considered the correct option, the treatment would be adequate in 100% of the prescriptions.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Community-acquired pneumonia/drug therapy ; Pneumonia ventilator-associated/drug therapy ; Anti-bacterial agents/therapeutic use ; Advance directive adherence
Publicat a:	Revista Brasileira de Terapia Intensiva, Vol. 27 (2015) , p. 44-50, ISSN 1982-4335

DOI: 10.5935/0103-507X.20150008
PMID: 25909312

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