Expression of IL-1α correlates with distant metastasis in patients with head and neck squamous cell carcinoma
León i Vintró, Xavier (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN))
Bothe González, Carolina (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya). Departament d'Otorinolaringologia)
García Lorenzo, Jacinto (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya). Departament d'Otorinolaringologia)
Parreño, Matilde (Institut d'Investigació Biomèdica Sant Pau)
Alcolea, Sonia (Institut d'Investigació Biomèdica Sant Pau)
Quer, Miquel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya). Departament d'Otorinolaringologia)
Vila Navarro, Luis (Institut d'Investigació Biomèdica Sant Pau)
Camacho Pérez de Madrid, Mercedes (Institut d'Investigació Biomèdica Sant Pau)

Date: 2015
Abstract: The presence of IL-1 in human cancers is associated with aggressive tumor biology but its prognostic value is unknown. We studied whether IL-1α expression is a prognostic marker of distant metastasis in patients with head and neck squamous cell carcinoma (HNSCC). IL-1α mRNA and protein levels were determined in tumor samples and cancer cell lines using RT-PCR and ELISA. The effects of constitutive IL-1α expression by tumor lines were characterized. IL-1α mRNA and protein secretion were higher in tumor samples from patients who later developed distant metastasis than in patients who did not. By using distant metastasis as a dependent variable, patients were classified into two categories of IL-1α transcript-levels. The high-IL-1α group had a significantly lower five-year distant metastasis-free survival than the low-IL-1α group [70. 0% (CI 95%: 55. 9-84. 1%) vs 94. 7% (CI 95%:90. 2-99. 2%)]. When IL-1α transcript-levels were combined with clinical factors related to tumor metastasis, the predictive power of the model increased significantly. Additionally, transcript levels of IL-1α correlated significantly with those of the IL-1 family genes and genes related to the metastatic process. IL-1 treatment of microvascular endothelial cells increased adhesion of HNSCC cells but no differences were found based on constitutive IL-1α expression by tumor cells. Nevertheless, IL-1α produced by tumor cells effectively increased their transmigration across the endothelium. We found a significant relationship between IL-1α expression and development of distant metastasis in HNSCC patients. IL-1α expression could help to define a subset of patients at high risk of distant metastasis who could benefit from adjuvant treatment.
Note: Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER)
Note: Número d'acord de subvenció ISCIII/FIS/PI14/01918
Note: Número d'acord de subvenció ISCIII/SAF2013-46707-R
Note: Número d'acord de subvenció ISCIII/RD12/0042/0051
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Cap ; Càncer ; Coll ; Head and neck cancer ; IL-1α ; Metastasis ; Prognosis ; Càncer de cap i coll ; Metastasi
Published in: Oncotarget, Vol. 6 (october 2015) , p. 37398-37409, ISSN 1949-2553

PMID: 26460957


12 p, 2.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació Biomèdica Sant Pau
Articles > Research articles
Articles > Published articles

 Record created 2018-01-31, last modified 2019-02-06



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