Scopus: 21 cites, Google Scholar: cites,
Bacterial flora in the sputum and comorbidity in patients with acute exacerbations of COPD
Boixeda, Ramon (Hospital de Mataró)
Almagro, Pere (Universitat de Barcelona)
Díez-Manglano, Jesús (Internal Medicine Department, Hospital Royo VillanovaZaragoza, Spain)
Cabrera, Francisco Javier (Hospital General Universitario Gregorio Marañón)
Recio, Jesús (Hospital Universitari Vall d'Hebron)
Martin-Garrido, Isabel (Internal Medicine Department, Hospital Quirón San Camilo)
Soriano, Joan B (Instituto de Investigación Hospital Universitario de la Princesa)
Universitat Autònoma de Barcelona

Data: 2015
Resum: To determine in patients admitted with an acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) the association between the isolation of potential pathogens in a conventional sputum culture and comorbidities. The ESMI study is a multicenter observational study. Patients with AE-COPD admitted to the Internal Medicine departments of 70 hospitals were included. The clinical characteristics, treatments, and comorbidities were gathered. The results of conventional sputum cultures were recorded. A total of 536 patients were included, of which 161 produced valid sputum and a potentially pathogenic microorganism was isolated from 88 subjects (16. 4%). The isolation of Pseudomonas aeruginosa (30. 7%) was associated with a greater severity of the lung disease (previous admissions [ P = 0. 026], dyspnea scale [ P =0. 047], post-broncodilator forced expiratory volume in 1 second (FEV) [ P =0. 005], and the BODEx index [ P =0. 009]); also with higher prevalence of cor pulmonale (P =0. 017), heart failure (P =0. 048), and cerebrovascular disease (P =0. 026). Streptococcus pneumoniae (26. 1%) was associated with more comorbidity according to number of diseases (P =0. 018); notably, peripheral artery disease (P =0. 033), hypertension (P =0. 029), dyslipidemia (P =0. 039), osteoporosis (P =0. 0001), and depression (P =0. 005). Patients with AE-COPD and P. aeruginosa present higher severity of COPD, while those with S. pneumoniae present greater comorbidity. The potentially pathogenic microorganism obtained in the sputum culture depends on the associated comorbidities.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Chronic obstructive pulmonary disease ; Comorbidities ; Hospitalization ; Sputum culture ; Etiology of exacerbations
Publicat a: International journal of COPD, Vol. 10 (december 2015) , p. 2581-2591, ISSN 1178-2005

DOI: 10.2147/COPD.S88702
PMID: 26664106


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