Web of Science: 20 citations, Google Scholar: citations
Coordinate responses to alkaline pH stress in budding yeast
Serra Cardona, Albert (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Canadell i Sala, David (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)

Date: 2015
Abstract: Alkalinization of the medium represents a stress condition for the budding yeast Saccharomyces cerevisiae to which this organism responds with profound remodeling of gene expression. This is the result of the modulation of a substantial number of signaling pathways whose participation in the alkaline response has been elucidated within the last ten years. These regulatory inputs involve not only the conserved Rim101/PacC pathway, but also the calcium-activated phosphatase calcineurin, the Wsc1-Pkc1-Slt2 MAP kinase, the Snf1 and PKA kinases and oxidative stress-response pathways. The uptake of many nutrients is perturbed by alkalinization of the environment and, consequently, an impact on phosphate, iron/copper and glucose homeostatic mechanisms can also be observed. The analysis of available data highlights cases in which diverse signaling pathways are integrated in the gene promoter to shape the appropriate response pattern. Thus, the expression of different genes sharing the same signaling network can be coordinated, allowing functional coupling of their gene products.
Note: Número d'acord de subvenció MINECO/BFU2014-54591-C2-1-P
Note: Número d'acord de subvenció MINECO/BFU2011-30197-C3-01
Note: Número d'acord de subvenció MINECO/EUI2009-04147
Note: Número d'acord de subvenció AGAUR/2014/SGR-4
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l’obra i la creació d’obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l’autoria de l’obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Calcineurin ; Snf1 ; PKA ; Transcriptomics ; S. cerevisiae
Published in: Microbial cell, Vol. 2, issue 6 (June 2015) , p. 182-196, ISSN 2311-2638

PMID: 28357292
DOI: 10.15698/mic2015.06.205


15 p, 2.2 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2018-01-31, last modified 2019-05-09



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