Neuroprotective Effects of Exercise Treatments After Injury : The Dual Role of Neurotrophic Factors
Cobianchi, Stefano (Universitat Autònoma de Barcelona. Institut de Neurociències)
Arbat-Plana, Ariadna (Universitat Autònoma de Barcelona. Institut de Neurociències)
López-Álvarez, Víctor M. (Universitat Autònoma de Barcelona. Institut de Neurociències)
Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)

Data:	2017
Resum:	Shared connections between physical activity and neuroprotection have been studied for decades, but the mechanisms underlying this effect of specific exercise were only recently brought to light. Several evidences suggest that physical activity may be a reasonable and beneficial method to improve functional recovery in both peripheral and central nerve injuries and to delay functional decay in neurodegenerative diseases. In addition to improving cardiac and immune functions, physical activity may represent a multifunctional approach not only to improve cardiocirculatory and immune functions, but potentially modulating trophic factors signaling and, in turn, neuronal function and structure at times that may be critical for neurodegeneration and regeneration. Research content related to the effects of physical activity and specific exercise programs in normal and injured nervous system have been reviewed. Sustained exercise, particularly if applied at moderate intensity and early after injury, exerts anti-inflammatory and pro-regenerative effects, and may boost cognitive and motor functions in aging and neurological disorders. However, newest studies show that exercise modalities can differently affect the production and function of brain-derived neurotrophic factor and other neurotrophins involved in the generation of neuropathic conditions. These findings suggest the possibility that new exercise strategies can be directed to nerve injuries with therapeutical benefits. Considering the growing burden of illness worldwide, understanding of how modulation of neurotrophic factors contributes to exercise-induced neuroprotection and regeneration after peripheral nerve and spinal cord injuries is a relevant topic for research, and represents the beginning of a new non-pharmacological therapeutic approach for better rehabilitation of neural disorders.
Ajuts:	European Commission 278612 European Commission 602547
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Exercise ; Inflammation ; Neurotrophic factors ; Neuropathic pain ; Nerve injury ; Nerve regeneration ; Survival
Publicat a:	Current neuropharmacology, Vol. 15 (may 2017) , p. 495-518, ISSN 1875-6190

DOI: 10.2174/1570159X14666160330105132
PMID: 27026050

24 p, 3.2 MB

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