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Treatment of patients with COPD and recurrent exacerbations : the role of infection and inflammation
Santos, Salud (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain)
Marin, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Serra-Batlles, Joan (Hospital Universitari de Vic)
de la Rosa, David (Hospital Plató)
Solanes, Ingrid (Institut d'Investigació Biomèdica Sant Pau)
Pomares, Xavier (Hospital Universitari Parc Taulí)
López-Sánchez, Marta (Hospital Universitari de Bellvitge)
Muñoz-Esquerre, Mariana (Hospital Universitari de Bellvitge)
Miravitlles, Marc (Hospital Universitari Vall d'Hebron)

Date: 2016
Abstract: Exacerbations of COPD represent an important medical and health care problem. Certain susceptible patients suffer recurrent exacerbations and as a consequence have a poorer prognosis. The effects of bronchial infection, either acute or chronic, and of the inflammation characteristic of the disease itself raise the question of the possible role of antibiotics and anti-inflammatory agents in modulating the course of the disease. However, clinical guidelines base their recommendations on clinical trials that usually exclude more severe patients and patients with more comorbidities, and thus often fail to reflect the reality of clinicians attending more severe patients. In order to discuss aspects of clinical practice of relevance to pulmonologists in the treatment and prevention of recurrent exacerbations in patients with severe COPD, a panel discussion was organized involving expert pulmonologists who devote most of their professional activity to day hospital care. This article summarizes the scientific evidence currently available and the debate generated in relation to the following aspects: bacterial and viral infections, chronic bronchial infection and its treatment with cyclic oral or inhaled antibiotics, inflammatory mechanisms and their treatment, and the role of computerized tomography as a diagnostic tool in patients with severe COPD and frequent exacerbations.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: COPD exacerbation ; Treatment ; Bronchial infection ; Anti-inflammatory treatment ; Antibiotics
Published in: International journal of chronic obstructive pulmonary disease, Vol. 11 (march 2016) , p. 515-525, ISSN 1178-2005

PMID: 27042040
DOI: 10.2147/COPD.S98333


11 p, 303.7 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació Biomèdica Sant Pau
Articles > Research articles
Articles > Published articles

 Record created 2018-02-07, last modified 2019-11-06



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