Insights on adaptive and innate immunity in canine leishmaniosis
Hosein, Shazia (University of London)
Blake, Damer P. (University of London)
Solano Gallego, Laia Maria (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)

Date:	2016
Abstract:	Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities. Clinical manifestations can range from subclinical infection to very severe systemic disease. Leishmaniosis is categorized as a neglected tropical disease and the complex immune responses associated with Leishmania species makes therapeutic treatments and vaccine development challenging for both dogs and humans. In this review, we summarize innate and adaptive immune responses associated with L. infantum infection in dogs, and we discuss the problems associated with the disease as well as potential solutions and the future direction of required research to help control the parasite.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Canine leishmaniosis ; Immunology ; Toll-like receptors ; Cytokine profiles ; T-cell mediated immunity
Published in:	Parasitology, Vol. 144 (april 2016) , p. 95-115, ISSN 1469-8161

DOI: 10.1017/S003118201600055X
PMID: 27094260

21 p, 319.5 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Grup de Recerca Malalties infeccioses-inflamatòries en animals de companyia (MIAC)
Articles > Research articles
Articles > Published articles