Posttraining epinephrine reverses memory deficits produced by traumatic brain injury in rats
Lorón Sánchez, Alejandro (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Torras Garcia, Meritxell (Universitat Autònoma de Barcelona. Institut de Neurociències)
Coll-Andreu, Margalida (Coll Andreu) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Costa Miserachs, David (Universitat Autònoma de Barcelona. Institut de Neurociències)
Portell Cortés, Isabel (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date:	2016
Abstract:	The aim of this research is to evaluate whether posttraining systemic epinephrine is able to improve object recognition memory in rats with memory deficits produced by traumatic brain injury. Forty-nine two-month-old naïve male Wistar rats were submitted to surgical procedures to induce traumatic brain injury (TBI) or were sham-operated. Rats were trained in an object recognition task and, immediately after training, received an intraperitoneal injection of distilled water (Sham-Veh and TBI-Veh group) or 0. 01 mg/kg epinephrine (TBI-Epi group) or no injection (TBI-0 and Sham-0 groups). Retention was tested 3 h and 24 h after acquisition. The results showed that brain injury produced severe memory deficits and that posttraining administration of epinephrine was able to reverse them. Systemic administration of distilled water also had an enhancing effect, but of a lower magnitude. These data indicate that posttraining epinephrine and, to a lesser extent, vehicle injection reduce memory deficits associated with TBI, probably through induction of a low-to-moderate emotional arousal.
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Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Scientifica, Vol. 2016 (april 2016) , ISSN 2090-908X

DOI: 10.1155/2016/9151490
PMID: 27127685

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
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Articles > Published articles