Basophil Activation Test identifies the patients with Chronic Spontaneous Urticaria suffering the most active disease
Curto-Barredo, Laia (Institut Hospital del Mar d'Investigacions Mèdiques)
Yélamos, José (Institut Hospital del Mar d'Investigacions Mèdiques)
Gimeno Martínez, Ramón (Institut Hospital del Mar d'Investigacions Mèdiques)
Mojal, Sergi (Institut Hospital del Mar d'Investigacions Mèdiques)
Pujol Vallverdú, Ramón M (Institut Hospital del Mar d'Investigacions Mèdiques)
Giménez-Arnau, Ana M.. 1961- (Institut Hospital del Mar d'Investigacions Mèdiques)
Universitat Autònoma de Barcelona

Data:	2016
Resum:	The basophil activation test showing CD63 up regulation could be a specific and sensitive in vitro complementary text to the in vivo autologous serum skin test for the activity assessment of the patients suffering autoimmune chronic spontaneous urticaria. The aim of this study is to define the basophil activation test as a useful tool in clinical practice in order to identify those patients with more active disease. We screened 139 patients (96 women) diagnosed of chronic spontaneous urticaria using simultaneously autologous serum skin test and basophil activation test and their relationship with disease activity. Positive autologous serum skin test was found in 56. 8%; from them, 31. 6% were basophil activation test positive. Negative autologous serum skin test result was found in the 43. 2% of the sample that showed negative CD63 expression results in all cases, except one. Patients with positive autologous serum skin test and positive CD63 by basophil activation test showed significant higher Urticaria Activity Score of 7 days (P = 0. 004) and of 3 weeks (P = 0. 001) than patients with positive autologous serum skin test and negative CD63 (mean ± standard deviation [SD] 26. 57 ± 10. 56 versus 18. 40 ± 12. 05 for the Urticaria Activity Score of 7 days and 56. 47 ± 23. 78 versus 39. 88 ± 25. 44 for the Urticaria Activity Score of 3 weeks). The CD63 expression on basophils appears as a reliable in vitro marker, useful in clinical practice in combination with autologous serum skin test to define chronic spontaneous urticaria patients with the highest urticaria activity that impairs a normal life.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Autologous serum skin test ; Basophil activation test ; Chronic spontaneous urticaria
Publicat a:	Immunity, Inflammation and Disease, Vol. 4 (october 2016) , p. 441-445, ISSN 2050-4527

DOI: 10.1002/iid3.125
PMID: 27980778

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