Home > Articles > Published articles > Tuning the endocytosis mechanism of Zr-based metal-organic frameworks through linker functionalization |
Date: | 2017 |
Abstract: | A critical bottleneck for the use of metal-organic frameworks (MOFs) as drug delivery systems has been allowing them to reach their intracellular targets without being degraded in the acidic environment of the lysosomes. Cells take up particles by endocytosis through multiple biochemical pathways, and the fate of these particles depends on these routes of entry. Here, we show the effect of functional group incorporation into a series of Zr-based MOFs on their endocytosis mechanisms, allowing us to design an efficient drug delivery system. In particular, naphthalene-2,6-dicarboxylic acid and 4,4'-biphenyldicarboxylic acid ligands promote entry through the caveolin -pathway, allowing the particles to avoid lysosomal degradation and be delivered into the cytosol and enhancing their therapeutic activity when loaded with drugs. |
Grants: | European Commission 726380 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-80 Ministerio de Economía y Competitividad MAT2015-65354-C2-1-R European Commission 615954 Ministerio de Economía y Competitividad SEV-2013-0295 |
Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Language: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Subject: | Metal−organic frameworks ; Mmetabolic pathways ; Drug delivery ; Endocytosis |
Published in: | ACS applied materials & interfaces, Vol. 9, Issue 41 (October 2017) , p. 35516-35525, ISSN 1944-8252 |
10 p, 2.4 MB |