Effectiveness of treatment with nebulized colistin in patients with COPD
Bruguera Àvila, Núria ![ORCID Identifier](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Departament de Medicina)
Marín, Alicia ![ORCID Identifier](/img/uab/orcid.ico)
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Garcia-Olivé, Ignasi ![ORCID Identifier](/img/uab/orcid.ico)
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Radua, Joaquim ![ORCID Identifier](/img/uab/orcid.ico)
(Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience)
Prat i Aymerich, Cristina ![ORCID Identifier](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Gil, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ruiz Manzano, J..
(Universitat Autònoma de Barcelona. Departament de Medicina)
Date: |
2017 |
Abstract: |
To analyze whether the introduction of nebulized colistin in patients with chronic obstructive pulmonary disease (COPD) and infection with Pseudomonas aeruginosa (PA) is associated with a decrease of the number and duration of severe exacerbations. Thirty six patients with COPD and infection with PA treated with nebulized colistin attending a day hospital during a 5-year (January 2010-December 2014) period were prospectively included. Repeated-measures t -tests were used to assess whether the introduction of colistin was associated with changes in the number of exacerbations or the length of the hospitalizations, comparing for each patient the year prior to the introduction of colistin with the year after. After the introduction of colistin, the number of admissions decreased from 2. 0 to 0. 9 per individual year (P =0. 0007), and hospitalizations were shorter (23. 3 vs 10. 9 days, P =0. 00005). These results persisted when patients with and without bronchiectasis or with and without persistence of Pseudomonas were separately analyzed. No pre-post differences were detected in the number of exacerbations not requiring admission. Nebulized colistin seems associated with a strong decrease in the number and duration of hospitalizations due to exacerbation in patients with COPD and infection with PA. Clinical trials with a larger number of patients are needed in order to confirm these results. |
Rights: |
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Language: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Subject: |
Bronchiectasis ;
Colistin ;
COPD ;
Nebulized antibiotics |
Published in: |
International journal of COPD, Vol. 12 (october 2017) , p. 2909-2915, ISSN 1178-2005 |
DOI: 10.2147/COPD.S138428
PMID: 29042767
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Record created 2018-02-08, last modified 2023-10-06