Web of Science: 8 citations, Scopus: 10 citations, Google Scholar: citations
MultitaskProtDB-II : an update of a database of multitasking/moonlighting proteins
Franco-Serrano, Luís (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Hernández, Sergio (Universitat Autònoma de Barcelona. Departamento de Bioquímia i Biologia Molecular)
Calvo, Alejandra (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología)
Severi, María A. (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología)
Ferragut, Gabriela (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología)
Pérez-Pons, Josep A. (Josep Antoni) (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Piñol Ribas, Jaume (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Pich, Òscar M. (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Mozo Villarias, Ángel (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Amela, Isaac (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Querol Murillo, Enrique (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Cedano Rodríguez, Juan Antonio (Universidad de la República Regional Norte-Salto. Laboratorio de Inmunología)

Date: 2017
Abstract: Multitasking, or moonlighting, is the capability of some proteins to execute two or more biological functions. MultitaskProtDB-II is a database of multifunctional proteins that has been updated. In the previous version, the information contained was: NCBI and UniProt accession numbers, canonical and additional biological functions, organism, monomeric/oligomeric states, PDB codes and bibliographic references. In the present update, the number of entries has been increased from 288 to 694 moonlighting proteins. MultitaskProtDB-II is continually being curated and updated. The new database also contains the following information: GO descriptors for the canonical and moonlighting functions, three-dimensional structure (for those proteins lacking PDB structure, a model was made using Itasser and Phyre), the involvement of the proteins in human diseases (78% of human moonlighting proteins) and whether the protein is a target of a current drug (48% of human moonlighting proteins). These numbers highlight the importance of these proteins for the analysis and explanation of human diseases and target-directed drug design. Moreover, 25% of the proteins of the database are involved in virulence of pathogenic microorganisms, largely in the mechanism of adhesion to the host. This highlights their importance for the mechanism of microorganism infection and vaccine design. MultitaskProtDB-II is available at http://wallace. uab. es/multitaskII.
Note: Número d'acord de subvenció MINECO/BIO2013–48704-R
Note: Número d'acord de subvenció MINECO/BFU2013–50176-EXP
Note: Número d'acord de subvenció MINECO/BIO2013–48704-R
Note: Número d'acord de subvenció MINECO/BFU2013–50176-EXP
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Published in: Nucleic acids research, Vol. 46, Database issue D645–D648 (2018) , p. D645-D648, ISSN 1362-4962

PMID: 29136215
DOI: 10.1093/nar/gkx1066


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 Record created 2018-02-08, last modified 2019-09-26



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