Web of Science: 21 citations, Scopus: 23 citations, Google Scholar: citations,
Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
Urrea, Laura (Barcelona, Spain)
Segura-Feliu, Miriam (Barcelona, Spain)
Masuda-Suzukake, Masami (Setagaya-ku, Tokyo, 156-8506 Japan)
Hervera Abad, Arnau (Barcelona, Spain)
Pedraz, Lucas (Barcelona, Spain)
García Aznar, José Manuel (Zaragoza, Spain)
Vila, Miquel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Samitier, Josep (Madrid, Spain)
Torrents, Eduard (Barcelona, Spain)
Ferrer, Isidro (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain)
Gavín, Rosalina (Barcelona, Spain)
Hagesawa, Masato (Setagaya-ku, Tokyo, 156-8506 Japan)
del Río, José Antonio (Barcelona, Spain)
Universitat Autònoma de Barcelona

Date: 2017
Abstract: The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of β-amyloid. Their interaction is mandatory for neurotoxic effects of βamyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of α-synuclein. Results demonstrate that Prnp expression is not mandatory for α-synuclein spreading. However, although the pathological spreading of αsynuclein can take place in the absence of Prnp, αsynuclein expanded faster in PrPC-overexpressing mice.
Note: Altres ajuts: The authors thank Tom Yohannan for the editorial advice and the IBEC Nanotechnology Platform staff for their generous help. This research was supported by grants from CIBERNED (PI2014/02-4 (Rapid dementias), PRY-14-114 and PRY2016-02, La Caixa Obra Social Foundation and La Marató de TV3) to J.A.D.R. M.S.-F was supported by CIBERNED, A.H was supported by La Caixa Obra Social Foundation and L.U. was supported by a fellowship from the Marató TV3 foundation.
Note: info:eurepo/grantAgreement/MINECO/FEDER/BFU2015-67777-R
Note: info:eurepo/grantAgreement/MINECO/FEDER/AGL2015-71764-REDT
Note: info:eurepo/grantAgreement/MINECO/FEDER/BIO2015-63557-R
Note: info:eurepo/grantAgreement/MINECO/FEDER/TEC2015-72718-EXP
Note: info:eurepo/grantAgreement/MINECO/DPI2015-64221-C2-1-R
Note: info:eurepo/grantAgreement/ISCIII/FEDER/FIS PIE14-00034
Note: info:eurepo/grantAgreement/ISCIII/FEDER/PI14-00757
Note: Número d'acord de subvenció ISCIII/PI10-01171
Note: Número d'acord de subvenció EC/228685-2
Note: Número d'acord de subvenció AGAUR/SGR2014-1218
Note: Número d'acord de subvenció AGAUR/2015-FI-B-00817
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan aquestes es distribueixin sota la mateixa llicència que regula l'obra original i es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Synuclein ; Amyloid spreading ; Prnp ; Microfluidic devices
Published in: Molecular neurobiology, Vol. 55 (february 2017) , p. 1847-1860, ISSN 1559-1182

DOI: 10.1007/s12035-017-0451-4
PMID: 28229331


14 p, 17.9 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2018-03-26, last modified 2020-11-03



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