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Antibodies against cell adhesion molecules and neural structures in paraneoplastic neuropathies
Siles, Ana M. (Institut d'Investigació Biomèdica Sant Pau)
Martínez-Hernández, Eugenia (Institut d'Investigació Biomèdica August Pi Sunyer)
Araque, Josefa (Institut d'Investigació Biomèdica Sant Pau)
Diaz-Manera, Jordi (Universitat Autònoma de Barcelona. Departament de Medicina)
Rojas-Garcia, Ricard (Universitat Autònoma de Barcelona. Departament de Medicina)
Gallardo, Eduard (Centro para la Investigación Biomédica en Red en Enfermedades Raras (CIBERER))
Illa, Isabel (UInstitut d'Investigació Biomèdica Sant Pau)
Graus, Francesc (Institut d'Investigació Biomèdica August Pi Sunyer)
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau)

Date: 2018
Abstract: Paraneoplastic neurological syndromes () are rare neurological disorders in which ectopic expression of neural antigens by a tumor results in an autoimmune attack against the nervous system. Onconeural antibodies not only guide diagnosis but may also help detecting underlying malignancies. Our project aims to uncover new potential antibodies in paraneoplastic neuropathies (). Thirty-four patients fulfilling diagnostic criteria of possible (n = 9; 26. 5%) and definite (n = 25; 73. 5%) without onconeural antibodies and 28 healthy controls were included in our study. Sera were tested for known antibodies against neural cell adhesion molecules and screened for novel IgG and IgM reactivities against nerve components: dorsal root ganglia () neurons, motor neurons, and Schwann cells. Patients showing autoantibodies against any of these cell types were used for immunoprecipitation () studies. Overall, 9 (26. 5%) patients showed significant reactivity against neurons, motor neurons, or Schwann cells, whereas 5 (17. 9%) healthy controls only showed moderate reactivity. Compared with control sera, serum samples from patients with paraneoplastic sensory-motor neuropathies had a higher frequency of IgM antibodies against Schwann cells (0% vs. 40%; P = 0. 0028). No novel antigens were identified from our experiments. Antibodies against the neural adhesion molecules 1, 155, 140, 186, 1, L1, and the 1/1 complex were not detected in patients with . One (2. 9%) patient with and thymoma had 2 antibodies. Almost 30% of patients with harbor antibodies targeting neural structures, suggesting that novel neoplasm-associated antigens remain to be discovered.
Note: Número d'acord de subvenció ISCIII/FIS16/00627
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Published in: Annals of Clinical and Translational Neurology, Vol. 5 (march 2018) , p. 559-569, ISSN 2328-9503

PMID: 29761119
DOI: 10.1002/acn3.554


11 p, 581.9 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació Biomèdica Sant Pau
Articles > Research articles
Articles > Published articles

 Record created 2018-06-18, last modified 2020-02-29



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