Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death
Casadellà, Maria (Institut Germans Trias i Pujol. IrsiCaixa)
Cozzi-Lepri, Alessandro (Royal Free Hospital, London)
Phillips, Andrew (Royal Free Hospital, London)
Noguera-Julian, Marc (Institut Germans Trias i Pujol. IrsiCaixa)
Bickel, Markus (Goethe University)
Sedlacek, Dalibor (Charles University Hospital, Plzen, Česka ́Republika)
Zilmer, Kai (West-Tallinn Central Hospital, Tallinn,)
Clotet, Bonaventura (Institut Germans Trias i Pujol. IrsiCaixa)
Lundgren, Jens D. (CHIP, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen)
Paredes, Roger (Institut Germans Trias i Pujol. IrsiCaixa)
EuroSIDA in EuroCOORD
Universitat Autònoma de Barcelona

Date: 2017
Abstract: Objective. To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management. Design. Nested case-control study within the EuroSIDA cohort. Methods. Cases were subjects with AIDS or who died from any cause, with a plasma sample with HIV-1 RNA >1000 copies/mL available for tropism testing 3 to 12 months prior to the event. At least 1 control matched for age, HIV-1 RNA and HCV status at the time of sampling were selected per each case. Conditional logistic regression was used to investigate exposures associated with clinical progression to AIDS or death. A linear mixed model with random intercept was used to compare CD4+T-cell slopes by HIV tropism over the 12 months following the date of sampling. Results. The study included 266 subjects, 100 cases and 166 controls; one quarter had X4 HIV; 26% were ART-naïve. Baseline factors independently associated with clinical progression or death were female gender (OR = 2. 13 vs. male, 95CI = 1. 04, 4. 36), p = 0. 038), CD4+T-cell count (OR = 0. 90 (95CI = 0. 80, 1. 00) per 100 cells/mm3 higher, p = 0. 058), being on ART (OR = 2. 72 vs. being off-ART (95CI = 1. 15, 6. 41), p = 0. 022) and calendar year of sample [OR = 0. 84 (95CI = 0. 77, 0. 91) per more recent year, p<0. 001). Baseline tropism was not associated with the risk of clinical progression or death. CD4+T-cell slopes did not differ within or between tropism groups. Conclusions. The predictive role of plasma tropism determined using 454 sequencing in the context of people receiving cART with detectable VL is not helpful to identify subjects at higher risk for clinical progression to AIDS or death.
Note: Número d'acord de subvenció EC/BIOMED 1/CT97-1637
Note: Número d'acord de subvenció EC/BIOMED 2/CT37-2713
Note: Número d'acord de subvenció EC/QLK2-2000-00773
Note: Número d'acord de subvenció EC/LSHP-CT-2006-018632
Note: Número d'acord de subvenció EC/FP7/2007-2013/Eurocoord260694
Note: Número d'acord de subvenció ISCIII/RD12/0017/0002
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Published in: Plos one, 2017, p. 1-14



14 p, 954.2 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles

 Record created 2018-10-05, last modified 2019-07-17



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