Plasma HIV-1 Tropism and the Risk of Short- Term Clinical Progression to AIDS or Death
Casadellà, Maria (Institut Germans Trias i Pujol. IrsiCaixa)
Cozzi-Lepri, Alessandro (Royal Free Hospital, London)
Phillips, Andrew (Royal Free Hospital, London)
Noguera-Julian, Marc (Institut Germans Trias i Pujol. IrsiCaixa)
Bickel, Markus (Goethe University)
Sedlacek, Dalibor (Charles University Hospital, Plzen, Česka ́Republika)
Zilmer, Kai (West-Tallinn Central Hospital, Tallinn,)
Clotet, Bonaventura (Institut Germans Trias i Pujol. IrsiCaixa)
Lundgren, Jens D. (CHIP, Department of Infectious Diseases, Rigshospitalet, University of Copenhagen)
Paredes, Roger (Institut Germans Trias i Pujol. IrsiCaixa)
EuroSIDA in EuroCOORD
Universitat Autònoma de Barcelona

Fecha: 2017
Resumen: Objective. To investigate if plasma HIV-1 tropism testing could identify subjects at higher risk for clinical progression and death in routine clinical management. Design. Nested case-control study within the EuroSIDA cohort. Methods. Cases were subjects with AIDS or who died from any cause, with a plasma sample with HIV-1 RNA >1000 copies/mL available for tropism testing 3 to 12 months prior to the event. At least 1 control matched for age, HIV-1 RNA and HCV status at the time of sampling were selected per each case. Conditional logistic regression was used to investigate exposures associated with clinical progression to AIDS or death. A linear mixed model with random intercept was used to compare CD4+T-cell slopes by HIV tropism over the 12 months following the date of sampling. Results. The study included 266 subjects, 100 cases and 166 controls; one quarter had X4 HIV; 26% were ART-naïve. Baseline factors independently associated with clinical progression or death were female gender (OR = 2. 13 vs. male, 95CI = 1. 04, 4. 36), p = 0. 038), CD4+T-cell count (OR = 0. 90 (95CI = 0. 80, 1. 00) per 100 cells/mm3 higher, p = 0. 058), being on ART (OR = 2. 72 vs. being off-ART (95CI = 1. 15, 6. 41), p = 0. 022) and calendar year of sample [OR = 0. 84 (95CI = 0. 77, 0. 91) per more recent year, p<0. 001). Baseline tropism was not associated with the risk of clinical progression or death. CD4+T-cell slopes did not differ within or between tropism groups. Conclusions. The predictive role of plasma tropism determined using 454 sequencing in the context of people receiving cART with detectable VL is not helpful to identify subjects at higher risk for clinical progression to AIDS or death.
Nota: Número d'acord de subvenció EC/BIOMED 1/CT97-1637
Nota: Número d'acord de subvenció EC/BIOMED 2/CT37-2713
Nota: Número d'acord de subvenció EC/QLK2-2000-00773
Nota: Número d'acord de subvenció EC/LSHP-CT-2006-018632
Nota: Número d'acord de subvenció EC/FP7/2007-2013/Eurocoord260694
Nota: Número d'acord de subvenció ISCIII/RD12/0017/0002
Derechos: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Lengua: Anglès.
Documento: article ; recerca ; publishedVersion
Publicado en: Plos one, 2017, p. 1-14



14 p, 954.2 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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 Registro creado el 2018-10-05, última modificación el 2019-09-17



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