Web of Science: 6 citations, Scopus: 6 citations, Google Scholar: citations,
Preclinical carotid atherosclerosis in patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes and classical type 1 diabetes
Hernández, Marta (Hospital Universitari Arnau de Vilanova)
López, Carolina (Universitat de Lleida. Escola d'Infermeria)
Real, Jordi (Epidemiologia i Salut Pública, Universitat International de Catalunya)
Valls, Joan (Institut de Recerca Biomèdica de Lleida)
Ortega Martinez de Victoria, Emilio (Hospital Clínic. Departament d'Endocrinologia i Nutrició)
Vázquez, Federico (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rubinat, Esther (Universitat de Lleida. Escola d'Infermeria)
Granado Casas, Minerva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Alonso, Nuria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Molí, Teresa (Hospital Universitari Arnau de Vilanova)
Betriu, Angels (Institut de Recerca Biomèdica de Lleida)
Lecube, Albert (Hospital Universitari Arnau de Vilanova)
Fernández, Elvira (Hospital Universitari Arnau de Vilanova)
Leslie, Richard David (The Blizard Institute, Barts and the London School of Medicine and Dentistry, London)
Mauricio, Dídac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Date: 2017
Abstract: Background: LADA is probably the most prevalent form of autoimmune diabetes. Nevertheless, there are few data about cardiovascular disease in this group of patients. The aim of this study was to investigate the frequency of carotid atherosclerotic plaques in patients with LADA as compared with patients with classic type 1 diabetes and type 2 diabetes. Methods: Patients with LADA were matched for age and gender in different proportions to patients with type 2 diabetes, and classic type 1 diabetes. None of the patients had clinical cardiovascular disease. All subjects underwent B-mode carotid ultrasound to detect atheroma plaques. Demographics were obtained from all subjects. Results: We included 71 patients with LADA, 191 patients with type 2 diabetes and 116 patients with type 1 diabetes. Carotid atherosclerosis was more frequent in patients with LADA compared with type 2 diabetes (73. 2% vs. 56. 9%, P = 0. 0018) and classic type 1 diabetes (57. 1%, P = 0. 026); these changes occurred despite healthier macrovascular risk profiles in the former. Age (P < 0. 001), smoking (P = 0. 003) and hypertension (P = 0. 019) were independently associated with carotid atherosclerosis. Multiple plaques were also more frequent in patients with LADA as compared with classic type 1 diabetes and type 2 diabetes (45. 1% and 33. 6% vs. 27. 2%, respectively, P = 0. 022). The frequency of carotid plaques increased with increasing diabetes duration in LADA patients compared with type 2 diabetes (85. 7% vs. 58. 8%, inverse OR 5. 72 [1. 5–21. 8]; P = 0. 009). Conclusions: LADA patients do not present with less carotid atherosclerosis than patients with type 1 and type 2 diabetes. Their macrovascular risk occurs despite a healthier macrovascular risk profile than those patients with type 2 diabetes.
Note: Número d'acord de subvenció ISCIII/PI12/00183
Note: Número d'acord de subvenció ISCIII/PI15/00625
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Carotid plaque ; Atherosclerosis ; Late onset autoimmune diabetes ; LADA ; Type 1 diabetes ; Type 2 diabetes
Published in: Cardiovascular Diabetology, Vol. 16 Núm. 94 (2017) , p. 1-9

DOI: 10.1186/s12933-017-0576-9
PMID: 28750634


9 p, 859.1 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles

 Record created 2018-10-17, last modified 2019-05-20



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