MDMA-Induced Dissociative State not Mediated by the 5-HT2A Receptor
Puxty, Drew J. (Maastricht University. Department of Neuropsychology and Psychopharmacology)
Ramaekers, Johannes G. (Maastricht University. Department of Neuropsychology and Psychopharmacology)
De La Torre, Rafael (Institut Hospital del Mar d'Investigacions Mèdiques)
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Pizarro, Neus (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Pujadas, Mitona (Institut Hospital del Mar d'Investigacions Mèdiques)
Kuypers, Kim P. C. (Maastricht University. Department of Neuropsychology and Psychopharmacology)

Data:	2017
Resum:	Previous research has shown that a single dose of MDMA induce a dissociative state, by elevating feelings of depersonalization and derealization. Typically, it is assumed that action on the 5-HT2A receptor is the mechanism underlying these psychedelic experiences. In addition, other studies have shown associations between dissociative states and biological parameters (heart rate, cortisol), which are elevated by MDMA. In order to investigate the role of the 5-HT2 receptor in the MDMA-induced dissociative state and the association with biological parameters, a placebo-controlled withinsubject study was conducted including a single oral dose of MDMA (75 mg), combined with placebo or a single oral dose of the 5-HT2 receptor blocker ketanserin (40 mg). Twenty healthy recreational MDMA users filled out a dissociative states scale (CADSS) 90 min after treatments, which was preceded and followed by assessment of a number of biological parameters (cortisol levels, heart rate, MDMA blood concentrations). Findings showed that MDMA induced a dissociative state but this effect was not counteracted by pre-treatment with ketanserin. Heart rate was the only biological parameter that correlated with the MDMA-induced dissociative state, but an absence of correlation between these measures when participants were pretreated with ketanserin suggests an absence of directional effects of heart rate on dissociative state. It is suggested that the 5-HT2 receptor does not mediate the dissociative effects caused by a single dose of MDMA. Further research is needed to determine the exact neurobiology underlying this effect and whether these effects contribute to the therapeutic potential of MDMA.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2014SGR680
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	MDMA ; Dissociative state ; Cortisol ; Heart rate ; 5-HT2 receptor ; MDMA concentration ; Depersonalization ; Derealization
Publicat a:	Frontiers in Pharmacology, Vol. 8 Núm. 455 (july 2017) , ISSN 1663-9812

DOI: 10.3389/fphar.2017.00455
PMID: 28744219

9 p, 602.7 KB

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