Web of Science: 53 cites, Scopus: 55 cites, Google Scholar: cites,
Human Pancreatic ß Cell lncRNAs Control Cell-Specific Regulatory Networks
Akerman, Ildem (Institut d'Investigacions Biomèdiques August Pi I Sunyer)
Tu, Zhidong (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai)
Beucher, Anthony (Department of Medicine, Imperial College London)
Rolando, Delphine M.Y. (Department of Medicine, Imperial College London)
Sauty-Colace, Claire (Institut du cerveau et de la moelle. Hôpital Pitié-Salpêtrière)
Benazra, Marion (Institut du cerveau et de la moelle. Hôpital Pitié-Salpêtrière)
Nakic, Nikolina (Department of Medicine, Imperial College London)
Yang, Jialiang (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai)
Wang, Huan (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai)
Pasquali, Lorenzo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Moran, Ignasi (Department of Medicine, Imperial College London)
Garcia Hurtado, Javier (Institut d'Investigacions Biomèdiques August Pi I Sunyer)
Castro, Natalia (Institut d'Investigacions Biomèdiques August Pi I Sunyer)
Gonzalez Franco, Roser (Department of Medicine, Imperial College London)
Stewart, Andrew F. (Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai)
Bonner, Caroline (European Genomic Institute for Diabetes)
Piemonti, Lorenzo (Diabetes Research Institute (HSR-DRI), San Raffaele Scientific Institute)
Berney, Thierry (Cell Isolation and Transplantation Center, University of Geneva,)
Groop, Leif (Department of Clinical Sciences, Lund University Diabetes Centre)
Kerr-Conte, Julie (European Genomic Institute for Diabetes)
Pattou, Francois (European Genomic Institute for Diabetes)
Argmann, Carmen (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai)
Schadt, Eric (Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai)
Ravassard, Phillipe (Institut du cerveau et de la moelle. Hôpital Pitié-Salpêtrière)
Jorge Ferrer (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Universitat Autònoma de Barcelona

Data: 2017
Resum: Recent studies have uncovered thousands of long non-coding RNAs (lncRNAs) in human pancreatic ß cells. ß cell lncRNAs are often cell type specific and exhibit dynamic regulation during differentiation or upon changing glucose concentrations. Although these features hint at a role of lncRNAs in ß cell gene regulation and diabetes, the function of b cell lncRNAs remains largely unknown. In this study, we investigated the function of b cell-specific lncRNAs and transcription factors using transcript knockdowns and co-expression network analysis. This revealed lncRNAs that function in concert with transcription factors to regulate ß cell-specific transcriptional networks. We further demonstrate that the lncRNA PLUTO affects local 3D chromatin structure and transcription of PDX1, encoding a key ß cell transcription factor, and that both PLUTO and PDX1 are downregulated in islets from donors with type 2 diabetes or impaired glucose tolerance. These results implicate lncRNAs in the regulation of ß cell-specific transcription factor networks.
Nota: Número d'acord de subvenció EC/H2020/667191
Nota: Número d'acord de subvenció MINECO/FU2014-54284-R
Nota: Número d'acord de subvenció WT/WT101033
Nota: Número d'acord de subvenció NIH-BCBC/2U01 DK072473-06
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; recerca ; publishedVersion
Publicat a: Cell metabolism, Vol. 25 (february 2017) , p. 400-411

DOI: 10.1016/j.cmet.2016.11.016
PMID: 28041957


13 p, 3.4 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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 Registre creat el 2018-10-18, darrera modificació el 2019-07-21



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