Chemotherapeutic agent 5-fluorouracil increases survival of SOD1 mouse model of ALS
Rando, Amaya (Instituto de Investigación Sanitaria Aragón. Centro de Investigación Biomédica de Aragón (CIBA))
De La Torre, M. (Instituto de Investigación Sanitaria Aragón. Centro de Investigación Biomédica de Aragón (CIBA))
Martínez-Muriana, Anna (Universitat Autònoma de Barcelona. Institut de Neurociències)
Zaragoza, Pilar (Instituto de Investigación Sanitaria Aragón. Centro de Investigación Biomédica de Aragón (CIBA))
Musaro, A. (Center for Life Nano Science@Sapienza. Istituto Italiano di Tecnologia)
Hernández Estañol, Sara (Institut de Recerca Biomèdica de Lleida)
Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Toivonen, J. M. (Instituto de Investigación Sanitaria Aragón. Centro de Investigación Biomédica de Aragón (CIBA))
Osta, R. (Instituto de Investigación Sanitaria Aragón. Centro de Investigación Biomédica de Aragón (CIBA))

Date:	2019
Abstract:	Amyotrophic lateral sclerosis (ALS) is a lethal motor neuron disease with no cure. Currently there are only two ALS drugs approved by the FDA, both with a limited therapeutic effect. In the search for drug candidates for ALS, we studied the effect of known stem cell mobilizing agents (treatment) and antimetabolite 5-fluorouracil (5-FU) (anti-treatment) in SOD1G93A model of ALS. Surprisingly, we found that anti-cancer drug 5-FU increases lifespan, delays the disease onset and improves motor performance in ALS mice. Although we were not able to demonstrate the mechanistic basis of the beneficial 5-FU action in ALS mice, our findings suggest that 5-FU or similar drugs are possible drug candidates for the treatment of motor neuron diseases through drug repurposing.
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 14 Núm. 1 (january 2019) , p. e0210752, ISSN 1932-6203

DOI: 10.1371/journal.pone.0210752
PMID: 30640943

16 p, 1.8 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles