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Página principal > Artículos > Artículos publicados > High-resolution mapping of infraslow cortical brain activity enabled by graphene microtransistors |
Fecha: | 2019 |
Resumen: | Recording infraslow brain signals (<0. 1 Hz) with microelectrodes is severely hampered by current microelectrode materials, primarily due to limitations resulting from voltage drift and high electrode impedance. Hence, most recording systems include high-pass filters that solve saturation issues but come hand in hand with loss of physiological and pathological information. In this work, we use flexible epicortical and intracortical arrays of graphene solution-gated field-effect transistors (gSGFETs) to map cortical spreading depression in rats and demonstrate that gSGFETs are able to record, with high fidelity, infraslow signals together with signals in the typical local field potential bandwidth. The wide recording bandwidth results from the direct field-effect coupling of the active transistor, in contrast to standard passive electrodes, as well as from the electrochemical inertness of graphene. Taking advantage of such functionality, we envision broad applications of gSGFET technology for monitoring infraslow brain activity both in research and in the clinic. |
Ayudas: | European Commission 696656 European Commission 732032 Ministerio de Economía y Competitividad IJCI-2015-25201 Ministerio de Economía y Competitividad DPI2015-64358-C2-1-R Ministerio de Economía y Competitividad SEV-2015-0522 Ministerio de Economía y Competitividad BFU2017-85048-R Ministerio de Economía y Competitividad SEV-2017-0706 |
Derechos: | Tots els drets reservats. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió acceptada per publicar |
Materia: | Active transistors ; Brain activity ; Broad application ; Cortical spreading depression ; Electrode impedance ; High-resolution mapping ; Local field potentials ; Recording systems ; Animals ; Brain Mapping ; Frontal Lobe ; Graphite ; Microelectrodes ; Microtechnology ; Models, Molecular ; Molecular Conformation ; Rats ; Transistors, Electronic |
Publicado en: | Nature materials, Vol. 18, Issue 3 (March 2019) , p. 280-288, ISSN 1476-4660 |
Preprint 21 p, 1.9 MB |
Postprint 23 p, 1.8 MB |