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CREB Regulates Distinct Adaptive Transcriptional Programs in Astrocytes and Neurons.
Pardo Fernández, Luis (Universitat Autònoma de Barcelona. Institut de Neurociències)
Valor, Luis Miguel (Hospital Universitario Puerta del Mar (Cadis, Andalusia))
Eraso-Pichot, Abel (Universitat Autònoma de Barcelona. Institut de Neurociències)
Barco, Ángel (Universidad Miguel Hernández. Instituto de Neurociencias)
Golbano Rodríguez, Arantxa (Universitat Autònoma de Barcelona. Institut de Neurociències)
Hardingham, Giles E. (University of Edinburgh. Dementia Research Institute)
Masgrau Juanola, Roser (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Galea Rodríguez de Velasco, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date: 2017
Abstract: The cyclic AMP response element binding protein (CREB) is a primary hub of a activity-driven genetic programs in neurons controlling plasticity, neurogenesis and survival. By contrast, the gene networks coordinated by CREB in astrocytes are Unknown despite the fact that the astrocytic CREB is a also activity-driven and neuroprotective. Herein we identified the transcriptional programs regulated by CREB in astrocytes as compared to neurons using, as study materials, transcriptome databases of astrocyte exposed to weII-known activators of CREB-dependent transcription as well as publidy available transcriptomes of neuronal cultures. Functional CREB signatures were extracted from the transcriptomes using Gene Ontology, adult-brain gene lists generated by Translating Ribosome Affinity Purification (TRAP) and CREB-target gene repositories. We found minimal overlap between CREB signatures in astrocytes and neurons. In astrocytes, the top triad of functions regulated by CREB consists of'Gene expression', 'Mitochondria', and 'Signa Iling', while in neurons it is 'Neurotransmission', 'Signalling' and 'Gene expression', the latter being represented by different genes from those in astrocytes. The newly gene rated data bases Will provide a tool to explore novel means whereby CREB impinges on brain functions requiring adaptive, long-lasting changes by coordinating transcriptionaI cascades in astrocytes.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Published in: Scientific Reports, Vol. 7(2017) , art. 6390, ISSN 2045-2322

DOI: 10.1038/s41598-017-06231

14 p, 6.3 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2019-06-17, last modified 2019-09-12

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