Control of plastidial metabolism by the Clp protease complex
Rodríguez Concepción, Manuel (Centre de Recerca en Agrigenòmica)
D'Andrea, Lucio (Centre de Recerca en Agrigenòmica)
Pulido, Pablo (Centre de Recerca en Agrigenòmica)

Date:	2019
Abstract:	Plant metabolism is strongly dependent on plastids. Besides hosting the photosynthetic machinery, these endosymbiotic organelles synthesize starch, fatty acids, amino acids, nucleotides, tetrapyrroles, and isoprenoids. Virtually all enzymes involved in plastid-localized metabolic pathways are encoded by the nuclear genome and imported into plastids. Once there, protein quality control systems ensure proper folding of the mature forms and remove irreversibly damaged proteins. The Clp protease is the main machinery for protein degradation in the plastid stroma. Recent work has unveiled an increasing number of client proteins of this proteolytic complex in plants. Notably, a substantial proportion of these substrates are required for normal chloroplast metabolism, including enzymes involved in the production of essential tetrapyrroles and isoprenoids such as chlorophylls and carotenoids. The Clp protease complex acts in coordination with nuclear-encoded plastidial chaperones for the control of both enzyme levels and proper folding (i. e. activity). This communication involves a retrograde signaling pathway, similarly to the unfolded protein response previously characterized in mitochondria and endoplasmic reticulum. Coordinated Clp protease and chaperone activities appear to further influence other plastid processes, such as the differentiation of chloroplasts into carotenoid-accumulating chromoplasts during fruit ripening.
Grants:	Ministerio de Economía y Competitividad BIO2015-71703-REDT Ministerio de Economía y Competitividad BIO2017-90877-REDT Agencia Estatal de Investigación BIO2017-84041-P Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-710 Ministerio de Economía y Competitividad SEV-2015-0533
Rights:	Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.
Language:	Anglès
Document:	Article de revisió ; Article ; Versió acceptada per publicar
Subject:	Carotenoid ; Chaperone ; Chlorophyll ; Chloroplast ; Clp protease ; Chromoplasts ; Isoprenoid ; Proteostasis ; Tetrapyrrole ; Unfolded protein response
Published in:	Journal of experimental botany, Vol. 70, Issue 7 (March 2019) , p. 2049-2058, ISSN 1460-2431

DOI: 10.1093/jxb/ery441
PMID: 30576524

Postprint 27 p, 816.0 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > CRAG (Centre for Research in Agricultural Genomics)
Articles > Published articles