Boosted Regeneration and Reduced Denervated Muscle Atrophy by NeuroHeal in a Pre-clinical Model of Lumbar Root Avulsion with Delayed Reimplantation
Romeo-Guitart, David (Universitat Autònoma de Barcelona. Institut de Neurociències)
Forés Vineta, Joaquim (Hospital Clínic i Provincial de Barcelona)
Navarro, X. (Xavier) (Xavier)
(Universitat Autònoma de Barcelona. Institut de Neurociències)
Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències)
Date: |
2017 |
Abstract: |
The "gold standard" treatment of patients with spinal root injuries consists of delayed surgical reconnection of nerves. The sooner, the better, but problems such as injury-induced motor neuronal death and muscle atrophy due to long-term denervation mean that normal movement is not restored. Herein we describe a preclinical model of root avulsion with delayed reimplantation of lumbar roots that was used to establish a new adjuvant pharmacological treatment. Chronic treatment (up to 6 months) with NeuroHeal, a new combination drug therapy identified using a systems biology approach, exerted long-lasting neuroprotection, reduced gliosis and matrix proteoglycan content, accelerated nerve regeneration by activating the AKT pathway, promoted the formation of functional neuromuscular junctions, and reduced denervation-induced muscular atrophy. Thus, NeuroHeal is a promising treatment for spinal nerve root injuries and axonal regeneration after trauma. |
Rights: |
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Language: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Published in: |
Scientific reports, Vol. 7 (2017) , art. 12028, ISSN 2045-2322 |
DOI: 10.1038/s41598-017-11086-3
PMID: 28931824
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Record created 2019-06-18, last modified 2023-03-15