Neuroprotective drug for nerve trauma revealed using artificial intelligence
Romeo-Guitart, David ![ORCID Identifier](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Institut de Neurociències)
Forés Vineta, Joaquim ![ORCID Identifier](/img/uab/orcid.ico)
(Hospital Clínic i Provincial de Barcelona)
Herrando-Grabulosa, Mireia ![ORCID Identifier](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Institut de Neurociències)
Valls, Raquel (Anaxomics Biotech.)
Leiva-Rodríguez, Tatiana ![ORCID Identifier](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Institut de Neurociències)
Galea, Elena ![ORCID Identifier](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Institut de Neurociències)
González-Pérez, Francisco (Universitat Autònoma de Barcelona. Institut de Neurociències)
Navarro, X. (Xavier) (Xavier)
(Universitat Autònoma de Barcelona. Institut de Neurociències)
Petegnief, Valerie
(Institut de Recerca Biomèdica de Lleida)
Bosch i Merino, Assumpció
(Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Coma, Mireia (Anaxomics Biotech.)
Mas, José Manuel (Anaxomics Biotech.)
Casas Louzao, Caty
(Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Date: |
2018 |
Abstract: |
Here we used a systems biology approach and artifcial intelligence to identify a neuroprotective agent for the treatment of peripheral nerve root avulsion. Based on accumulated knowledge of the neurodegenerative and neuroprotective processes that occur in motoneurons after root avulsion, we built up protein networks and converted them into mathematical models. Unbiased proteomic data from our preclinical models were used for machine learning algorithms and for restrictions to be imposed on mathematical solutions. Solutions allowed us to identify combinations of repurposed drugs as potential neuroprotective agents and we validated them in our preclinical models. The best one, NeuroHeal, neuroprotected motoneurons, exerted anti-infammatory properties and promoted functional locomotor recovery. NeuroHeal endorsed the activation of Sirtuin 1, which was essential for its neuroprotective efect. These results support the value of network-centric approaches for drug discovery and demonstrate the efcacy of NeuroHeal as adjuvant treatment with surgical repair for nervous system trauma. |
Rights: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ![Creative Commons](/img/licenses/by.ico) |
Language: |
Anglès |
Document: |
Article ; recerca ; Versió publicada |
Published in: |
Scientific reports, Vol. 8 (2018) , art. 1879, ISSN 2045-2322 |
DOI: 10.1038/s41598-018-19767-3
PMID: 29382857
The record appears in these collections:
Research literature >
UAB research groups literature >
Research Centres and Groups (research output) >
Health sciences and biosciences >
Institut de Neurociències (INc)Articles >
Research articlesArticles >
Published articles
Record created 2019-06-18, last modified 2023-10-26