Web of Science: 8 citations, Scopus: 8 citations, Google Scholar: citations,
Neuroprotective drug for nerve trauma revealed using artificial intelligence.
Romeo Guitart, David (Universitat Autónoma de Barcelona. Institut de Neruorciències)
Forés Vineta, Joaquim (Universitat de Barcelona. Hospital Clínic)
Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Insitut de Neurociències)
Valls, Raquel (Anaxomics Biotech.)
Leiva Rodríguez, Tatiana (Universitat Autònoma de Barcelona. Institut de Neurociències)
Galea, Elena (Universitat Autònoma de Barcelona. Institut de Neurociències)
González-Pérez, Francisco (Universitat Autònoma de Barcelona. Institut de Neruociències)
Navarro, Xavier. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neruociències)
Petegnief, Valerie (Institut de Recerca Biomèdica de Barcelona(IBB))
Bosch i Merino, Assumpció (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Coma, Mireia (Anaxomics Biotech.)
Mas, José Manuel (Anaxomics Biotech.)
Casas Louzao, Caty (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)

Date: 2018
Abstract: Here we used a systems biology approach and artifcial intelligence to identify a neuroprotective agent for the treatment of peripheral nerve root avulsion. Based on accumulated knowledge of the neurodegenerative and neuroprotective processes that occur in motoneurons after root avulsion, we built up protein networks and converted them into mathematical models. Unbiased proteomic data from our preclinical models were used for machine learning algorithms and for restrictions to be imposed on mathematical solutions. Solutions allowed us to identify combinations of repurposed drugs as potential neuroprotective agents and we validated them in our preclinical models. The best one, NeuroHeal, neuroprotected motoneurons, exerted anti-infammatory properties and promoted functional locomotor recovery. NeuroHeal endorsed the activation of Sirtuin 1, which was essential for its neuroprotective efect. These results support the value of network-centric approaches for drug discovery and demonstrate the efcacy of NeuroHeal as adjuvant treatment with surgical repair for nervous system trauma.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Published in: Scientific reports, Vol. 8 (2018) , art. 1879, ISSN 2045-2322

DOI: 10.1038/s41598-018-19767-3
PMID: 29382857


15 p, 11.4 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2019-06-18, last modified 2020-01-22



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