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Distinctive Expression and Amplification of Genes at 11q13 in Relation to HPV Status with Impact on Survival in Head and Neck Cancer Patients
Hermida-Prado, Francisco (Centro de Investigación Biomédica en Red Cáncer (CIBERONC))
Menéndez, Sofía T. (Centro de Investigación Biomédica en Red Cáncer (CIBERONC))
Albornoz-Afanasiev, Pablo (Hospital Universitario Central de Asturias)
Granda-Diaz, Rocío (Centro de Investigación Biomédica en Red Cáncer (CIBERONC))
Álvarez-Teijeiro, Saúl (Centro de Investigación Biomédica en Red Cáncer (CIBERONC))
Villaronga, M. Ángeles (Centro de Investigación Biomédica en Red Cáncer (CIBERONC))
Allonca, Eva (Centro de Investigación Biomédica en Red Cáncer (CIBERONC))
Alonso-Durán, Laura (Hospital Universitario Central de Asturias)
León, Xavier (Institut d'Investigació Biomèdica Sant Pau)
Alemany, Laia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP))
Mena, Marisa (Institut Català d'Oncologia)
del-Rio-Ibisate, Nagore (Centro de Investigación Biomédica en Red Cáncer (CIBERONC))
Astudillo, Aurora (Hospital Universitario Central de Asturias)
Rodríguez, René (Centro de Investigación Biomédica en Red Cáncer (CIBERONC))
Rodrigo, Juan P. (Centro de Investigación Biomédica en Red Cáncer (CIBERONC))
García-Pedrero, Juana M. (Centro de Investigación Biomédica en Red Cáncer (CIBERONC))
Universitat Autònoma de Barcelona

Data: 2018
Resum: Clear differences have been established between head and neck squamous cell carcinomas (HNSCC) depending on human papillomavirus (HPV) infection status. This study specifically investigated the status of the CTTN, CCND1 and ANO1 genes mapping at the 11q13 amplicon in relation to the HPV status in HNSCC patients. CTTN, CCND1 and ANO1 protein expression and gene amplification were respectively analyzed by immunohistochemistry and real-time PCR in a homogeneous cohort of 392 surgically treated HNSCC patients. The results were further confirmed using an independent cohort of 279 HNSCC patients from The Cancer Genome Atlas (TCGA). The impact on patient survival was also evaluated. CTTN, CCND1 and ANO1 gene amplification and protein expression were frequent in HPV-negative tumors, while absent or rare in HPV-positive tumors. Using an independent validation cohort of 279 HNSCC patients, we consistently found that these three genes were frequently co-amplified (28%) and overexpressed (39–46%) in HPV-negative tumors, whereas almost absent in HPV-positive tumors. Remarkably, these alterations (in particular CTTN and ANO1 overexpression) were associated with poor prognosis. Taken together, the distinctive expression and amplification of these genes could cooperatively contribute to the differences in prognosis and clinical outcome between HPV-positive and HPV-negative tumors. These findings could serve as the basis to design more personalized therapeutic strategies for HNSCC patients.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès.
Document: article ; publishedVersion
Matèria: Head and neck squamous cell carcinoma ; HPV ; 11q13 ; Gene amplification ; Immunohistochemistry
Publicat a: Journal of Clinical Medicine, Vol. 7 (december 2018) , ISSN 2077-0383

PMID: 30513772
DOI: 10.3390/jcm7120501


14 p, 2.3 MB

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 Registre creat el 2019-08-12, darrera modificació el 2019-09-04



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