pH-Responsive Relaxometric Behaviour of Coordination Polymer Nanoparticles Made of a Stable Macrocyclic Gadolinium Chelate
Aríñez Soriano, Javier (Institut Català de Nanociència i Nanotecnologia)
Albalad Alcala, Jorge (Institut Català de Nanociència i Nanotecnologia)
Carné-Sánchez, Arnau (Institut Català de Nanociència i Nanotecnologia)
Bonnet, Célia S. (Université d'Orléans)
Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química)
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Juanhuix, Judith (ALBA Laboratori de Llum de Sincrotró)
Terban, Maxwell W. (Columbia University. Department of Applied Physics and Applied Mathematics)
Imaz, Inhar (Institut Català de Nanociència i Nanotecnologia)
Tóth, Éva (Université d'Orléans)
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia)

Date:	2016
Abstract:	Lanthanide-containing nanoscale particles have been widely explored for various biomedical purposes, however, they are often prone to metal leaching. Here we have created a new coordination polymer (CP) by applying, for the first time, a stable Gdchelate as building block in order to prevent any fortuitous release of free lanthanide(III) ion. The use of the Gd-DOTA-4AmP complex as a design element in the CP allows not only for enhanced relaxometric properties (maximum r=16. 4 mmsat 10 MHz), but also for a pH responsiveness (Δr=108 % between pH 4 and 6. 5), beyond the values obtained for the low molecular weight Gd-DOTA-4AmP itself. The CP can be miniaturised to the nanoscale to form colloids that are stable in physiological saline solution and in cell culture media and does not show cytotoxicity.
Grants:	Ministerio de Economía y Competitividad MAT2012-30994 Ministerio de Economía y Competitividad SEV-2013-0295
Rights:	Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Chelates ; Contrast agents ; Coordination polymers ; Gadolinium ; Relaxometry
Published in:	Chemistry (Weinheim), Vol. 22, Issue 37 (September 2016) , p. 13162-13170, ISSN 1521-3765

DOI: 10.1002/chem.201602356

Postprint 11 p, 695.3 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > The ALBA Synchrotron
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