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Pàgina inicial > Articles > Articles publicats > pH-Responsive Relaxometric Behaviour of Coordination Polymer Nanoparticles Made of a Stable Macrocyclic Gadolinium Chelate |
Data: | 2016 |
Resum: | Lanthanide-containing nanoscale particles have been widely explored for various biomedical purposes, however, they are often prone to metal leaching. Here we have created a new coordination polymer (CP) by applying, for the first time, a stable Gdchelate as building block in order to prevent any fortuitous release of free lanthanide(III) ion. The use of the Gd-DOTA-4AmP complex as a design element in the CP allows not only for enhanced relaxometric properties (maximum r=16. 4 mmsat 10 MHz), but also for a pH responsiveness (Δr=108 % between pH 4 and 6. 5), beyond the values obtained for the low molecular weight Gd-DOTA-4AmP itself. The CP can be miniaturised to the nanoscale to form colloids that are stable in physiological saline solution and in cell culture media and does not show cytotoxicity. |
Ajuts: | Ministerio de Economía y Competitividad MAT2012-30994 Ministerio de Economía y Competitividad SEV-2013-0295 |
Drets: | Tots els drets reservats. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió acceptada per publicar |
Matèria: | Chelates ; Contrast agents ; Coordination polymers ; Gadolinium ; Relaxometry |
Publicat a: | Chemistry, Vol. 22, Issue 37 (September 2016) , p. 13162-13170, ISSN 1521-3765 |
Postprint 11 p, 695.3 KB |