Pan-cancer analysis of whole genomes
Campbell, Peter J. (Wellcome Trust Sanger Institute (Regne Unit))
Getz, Gad (Harvard Medical School)
Korbel, Jan O. (European Molecular Biology Laboratory (EMBL). Genome Biology Unit)
Stuart, Joshua M. (Biomolecular Engineering Department. University of California Santa Cruz)
Jennings, Jennifer L. (International Cancer Genome Consortium (ICGC)/ICGC Accelerating Research in Genomic Oncology (ICGC-ARGO) Secretariat)
Stein, Lincoln D. (Department of Molecular Genetics. University of Toronto)
Perry, Marc D. (Genome Informatics Program. Ontario Institute for Cancer Research)
Nahal-Bose, Hardeep K. (Genome Informatics Program. Ontario Institute for Cancer Research)
Ouellette, B. F. Francis (Genome Informatics. Ontario Institute for Cancer Research)
Li, Constance H. (Department of Medical Biophysics. University of Toronto)
Rheinbay, Esther (Massachusetts General Hospital (Boston))
Nielsen, G. Petur (Massachusetts General Hospital (Boston))
Sgroi, Dennis C. (Massachusetts General Hospital (Boston))
Wu, Chin-Lee (Massachusetts General Hospital (Boston))
Faquin, William C. (Massachusetts General Hospital (Boston))
Deshpande, Vikram (Massachusetts General Hospital (Boston))
Boutros, Paul C. (University of California Los Angeles)
Lazar, Aalexander J. (Department of Pathology. Department of Genomic Medicine and Department of Translational Molecular Pathology. The University of Texas MD Anderson Cancer Center)
Hoadley, Katherine A. (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill)
Louis, David N. (Massachusetts General Hospital (Boston))
Yung, Christina K. (Genome Informatics Program. Ontario Institute for Cancer Research)
Bailey, Matthew H. (The McDonnell Genome Institute. Washington University)
Saksena, Gordon (Broad Institute of MIT and Harvard)
Raine, Keiran M. (Wellcome Trust Sanger Institute (Regne Unit))
Buchhalter, Ivo (Institute of Pharmacy and Molecular Biotechnology. and BioQuant. Heidelberg University)
Kleinheinz, Kortine (Institute of Pharmacy and Molecular Biotechnology. and BioQuant. Heidelberg University)
Schlesner, Matthias (German Cancer Research Center (DKFZ))
Zhang, Jiashan (National Cancer Institute. National Institutes of Health)
Wang, Wenyi (Department of Bioinformatics and Computational Biology. The University of Texas MD Anderson Cancer Center)
Wheeler, David A. (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Department of Molecular and Human Genetics)
Ding, Li (Department of Genetics and Department of Medicine. Washington University in St Louis)
Simpson, Jared T. (Department of Computer Science. University of Toronto)
O'Connor, Brian D. (University of California Santa Cruz)
Yakneen, Sergei (European Molecular Biology Laboratory (EMBL). Genome Biology Unit)
Ellrott, Kyle (Computational Biology Program. Oregon Health & Science University)
Miyoshi, Naoki (The Institute of Medical Science. The University of Tokyo)
Butler, Adam P. (Wellcome Trust Sanger Institute (Regne Unit))
Royo, Romina (Barcelona Supercomputing Center)
Shorser, Solomon I. (Computational Biology Program. Ontario Institute for Cancer Research)
Vazquez, Miguel (Department of Clinical and Molecular Medicine. Faculty of Medicine and Health Sciences. Norwegian University of Science and Technology)
Rausch, Tobias (European Molecular Biology Laboratory (EMBL). Genome Biology Unit)
Tiao, Grace (Broad Institute of MIT and Harvard)
Waszak, Sebastian M. (European Molecular Biology Laboratory (EMBL). Genome Biology Unit)
Rodriguez-Martin, Bernardo (The Biomedical Research Centre (CINBIO). Universidade de Vigo)
Shringarpure, Suyash (Department of Genetics. Stanford University School of Medicine)
Wu, Dai-Ying (Annai Systems)
Demidov, German M. (Universitat Pompeu Fabra)
Delaneau, Olivier (Swiss Institute of Bioinformatics. University of Geneva)
Hayashi, Shuto (The Institute of Medical Science. The University of Tokyo)
Imoto, Seiya (The Institute of Medical Science. The University of Tokyo)
Habermann, Nina (European Molecular Biology Laboratory (EMBL). Genome Biology Unit)
Segre, Ayellet V. (Department of Ophthalmology. Ocular Genomics Institute. Massachusetts Eye and Ear. Harvard Medical School)
Garrison, Erik (Wellcome Trust Sanger Institute (Regne Unit))
Cafferkey, Andy (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI))
Alvarez, Eva G. (The Biomedical Research Centre (CINBIO). Universidade de Vigo)
Heredia-Genestar, José María (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Muyas, Francesc (Universitat Pompeu Fabra)
Drechsel, Oliver (Universitat Pompeu Fabra)
Bruzos, Alicia L. (The Biomedical Research Centre (CINBIO). Universidade de Vigo)
Temes, Javier (Department of Zoology. Genetics and Physical Anthropology. Centre for Research in Molecular Medicine and Chronic Diseases (CiMUS). Universidade de Santiago de Compostela)
Zamora, Jorge (Wellcome Trust Sanger Institute (Regne Unit))
Baez-Ortega, Adrian (Department of Veterinary Medicine. Transmissible Cancer Group. University of Cambridge)
Kim, Hyung-Lae (Department of Biochemistry. College of Medicine. Ewha Womans University)
Mashl, R. Jay (Division of Oncology. Washington University School of Medicine)
Ye, Kai (The First Affiliated Hospital. Xi'an Jiaotong University)
DiBiase, Anthony
Huang, Kuan-Lin (Icahn School of Medicine at Mount Sinai (Nova York, Estats Units d'Amèrica))
Letunic, Ivica (Biobyte Solutions)
McLellan, Michael D. (Department of Genetics and Department of Medicine. Washington University in St Louis)
Newhouse, Steven J. (European Molecular Biology Laboratory (EMBL). European Bioinformatics Institute (EMBL-EBI))
Shmaya, Tal (Annai Systems)
Kumar, Sushant (Program in Computational Biology and Bioinformatics. Yale University)
Wedge, David C. (Wellcome Trust Sanger Institute (Regne Unit))
Wright, Mark H. (Department of Genetics. Stanford University School of Medicine)
Yellapantula, Venkata D. (The McDonnell Genome Institute at Washington University School of Medicine. and Department of Genetics and Department of Medicine. Siteman Cancer Center. Washington University in St Louis)
Gerstein, Mark (Department of Computer Science. Yale University)
Khurana, Ekta (Institute for Computational Biomedicine. Weill Cornell Medicine)
Marquès i Bonet, Tomàs 1975- (Institut Català de Paleontologia Miquel Crusafont)
Navarro, Arcadi 1969- (Institució Catalana de Recerca i Estudis Avançats)
Hosoda, Fumie (Division of Cancer Genomics. National Cancer Center Research Institute. National Cancer Center)
Nakamura, Hiromi (Division of Cancer Genomics. National Cancer Center Research Institute. National Cancer Center)
Ojima, Hidenori (Department of Pathology. Keio University School of Medicine)
Okusaka, Takuji (Department of Hepatobiliary and Pancreatic Oncology. National Cancer Center Hospital)
Totoki, Yasushi (Division of Cancer Genomics. National Cancer Center Research Institute. National Cancer Center)
Urushidate, Tomoko (Laboratory of Molecular Medicine. Human Genome Center. The Institute of Medical Science. The University of Tokyo)
Fukayama, Masashi (Department of Pathology. Graduate School of Medicine. The University of Tokyo. Bunkyo-ku)
Bustamante, Carlos D. (Department of Biomedical Data Science. Stanford University School of Medicine)
Ishikawa, Shumpei (Preventive Medicine. Graduate School of Medicine. The University of Tokyo)
Katai, Hitoshi (Gastric Surgery Division. Division of Pathology and Clinical Laboratories. National Cancer Center Hospital)
Katoh, Hiroto (Preventive Medicine. Graduate School of Medicine. The University of Tokyo)
Komura, Daisuke (Preventive Medicine. Graduate School of Medicine. The University of Tokyo)
Rokutan, Hirofumi (Department of Bioinformatics. Division of Cancer Genomics. National Cancer Center Research Institute. National Cancer Center)
Saito-Adachi, Mihoko (Department of Bioinformatics. Division of Cancer Genomics. National Cancer Center Research Institute. National Cancer Center)
Suzuki, Akihiro (Department of Gastroenterology and Hepatology. Yokohama City University Graduate School of Medicine)
Taniguchi, Hirokazu (Laboratory of Molecular Medicine. Human Genome Center. The Institute of Medical Science. University of Tokyo)
Tatsuno, Kenji (Genome Science Division. Research Center for Advanced Science and Technology. The University of Tokyo)
Ushiku, Tetsuo (Department of Pathology. Graduate School of Medicine. The University of Tokyo. Bunkyo-ku)
Siebert, Reiner (Institute of Human Genetics. Ulm University and Ulm University Medical Center)
Yachida, Shinichi (Department of Cancer Genome Informatics. Graduate School of Medicine. Osaka University)
Yamamoto, Shogo (Genome Science Division. Research Center for Advanced Science and Technology. The University of Tokyo)
Aikata, Hiroshi (Hiroshima University)
Arihiro, Koji (Hiroshima University)
Ariizumi, Shun-ichi (Tokyo Women's Medical University)
Chayama, Kazuaki (Hiroshima University)
Furuta, Mayuko (RIKEN Center for Integrative Medical Sciences)
Gotoh, Kunihito (Osaka International Cancer Center)
Hayami, Shinya (Wakayama Medical University)
Hirano, Satoshi (Hokkaido University)
Nakagawa, Hidewaki (RIKEN Center for Integrative Medical Sciences)
Kawakami, Yoshiiku (Hiroshima University)
Maejima, Kazuhiro (RIKEN Center for Integrative Medical Sciences)
Nakamura, Toru (Hokkaido University)
Nakano, Kaoru (RIKEN Center for Integrative Medical Sciences)
Ohdan, Hideki (Hiroshima University)
Sasaki-Oku, Aya (RIKEN Center for Integrative Medical Sciences)
Tanaka, Hiroko (The Institute of Medical Science. The University of Tokyo)
Ueno, Masaki (Wakayama Medical University)
Yamamoto, Masakazu (Tokyo Women's Medical University)
Yamaue, Hiroki (Wakayama Medical University)
Easton, Douglas F. (University of Cambridge. Centre for Cancer Genetic Epidemiology)
Choo, Su Pin (Division of Medical Oncology. National Cancer Centre)
Cutcutache, Ioana (Centre for Computational Biology. Duke-NUS Medical School)
Khuntikeo, Narong (Khon Kaen University. Faculty of Medicine)
Ong, Choon Kiat (Lymphoma Genomic Translational Research Laboratory. National Cancer Centre)
Pairojkul, Chawalit (Department of Clinical Pathology. University of Melbourne)
Popescu, Irinel (Center of Digestive Diseases and Liver Transplantation. Fundeni Clinical Institute)
Ahn, Keun Soo (Division of Hepatobiliary and Pancreatic Surgery. Department of Surgery. School of Medicine. Keimyung University Dongsan Medical Center)
Aymerich, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
López Guillermo, Armando (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
López-Otín, Carlos (Department of Biochemistry and Molecular Biology. Faculty of Medicine. University Institute of Oncology-IUOPA)
Ossowski, Stephan (Universitat Pompeu Fabra)
Puente, Xose S. (University of Oviedo)
Campo, Elias (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Amary, Fernanda (Royal National Orthopaedic Hospital (Bolsover))
Baumhoer, Daniel (Oslo University Hospital (Oslo, Noruega))
Behjati, Sam (Wellcome Trust Sanger Institute (Regne Unit))
Bjerkehagen, Bodil (Institute of Clinical Medicine and Institute of Oral Biology. University of Oslo)
Futreal, P. Andrew (National Genotyping Center. Institute of Biomedical Sciences. Academia Sinica)
Myklebost, Ola (Department of Clinical Science. University of Bergen)
Pillay, Nischalan (Research Department of Pathology. University College London Cancer Institute)
Tarpey, Patrick (East Anglian Medical Genetics Service. Cambridge University Hospitals NHS Foundation Trust)
Tubio, Jose M. C. (The Biomedical Research Centre (CINBIO). Universidade de Vigo)
Tirabosco, Roberto (Royal National Orthopaedic Hospital (Stanmore))
Zaikova, Olga (Oslo University Hospital (Oslo, Noruega))
Flanagan, Adrienne M. (Department of Pathology (Research). University College London Cancer Institute)
Boultwood, Jacqueline (University of Oxford. Radcliffe Department of Medicine)
Bowen, David T. (Wellcome Trust Sanger Institute (Regne Unit))
Cazzola, Mario (University of Pavia)
Green, Anthony R. (University of Cambridge)
Hellstrom-Lindberg, Eva (Karolinska Institutet (Estocolm, Suècia))
Malcovati, Luca (University of Pavia)
Nangalia, Jyoti (Wellcome Trust Sanger Institute (Regne Unit))
De La Vega, Francisco M. (Department of Biomedical Data Science. Stanford University School of Medicine)
Papaemmanuil, Elli (Wellcome Trust Sanger Institute (Regne Unit))
Vyas, Paresh (University of Oxford)
Ang, Yeng (Salford Royal NHS Foundation Trust (Salford, Regne Unit))
Barr, Hugh (Gloucester Royal Hospital)
Beardsmore, Duncan (Royal Stoke University Hospital)
Eldridge, Matthew (Cancer Research UK Cambridge Institute. University of Cambridge)
Gossage, James (St Thomas's Hospital)
Grehan, Nicola (MRC Cancer Unit. University of Cambridge)
Hanna, George B. (Imperial College NHS Trust. Imperial College London)
Hayes, Stephen J. (Faculty of Biology. Medicine and Health. The University of Manchester)
Estivill, Xavier (Quantitative Genomics Laboratories (qGenomics))
Hupp, Ted R. (Edinburgh Royal Infirmary)
Khoo, David (Barking Havering and Redbridge University Hospital (Barking, Regne Unit))
Lagergren, Jesper (King's College London)
Lovat, Laurence B. (University College London)
MacRae, Shona (Cancer Unit. MRC University of Cambridge)
O'Donovan, Maria (MRC Cancer Unit. University of Cambridge)
O'Neill, J. Robert (Cambridge University Hospitals NHS Foundation Trust (Anglaterra))
Parsons, Simon L. (Nottingham University Hospitals NHS Trust (Regne Unit))
Preston, Shaun R. (St Luke's Cancer Centre. Royal Surrey County Hospital NHS Foundation Trust)
Puig, Sonia (University of North Carolina at Chapel Hill)
Yuen, Denis (Computational Biology Program. Ontario Institute for Cancer Research)
Roques, Tom (Norfolk and Norwich University Hospital NHS Trust)
Sanders, Grant (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill)
Sothi, Sharmila (University Hospitals Coventry and Warwickshire NHS Trust)
Tavaré, Simon (Cancer Research UK Cambridge Institute. University of Cambridge)
Tucker, Olga (Birmingham Women's and Children's Hospital (Regne Unit))
Turkington, Richard (Centre for Cancer Research and Cell Biology. Queen's University)
Underwood, Timothy J. (School of Cancer Sciences. Faculty of Medicine. University of Southampton)
Welch, Ian (Wythenshawe Hospital)
Fitzgerald, Rebecca C. (MRC Cancer Unit. University of Cambridge)
Berney, Daniel M. (University of London)
Mihaiescu, George L. (Genome Informatics Program. Ontario Institute for Cancer Research)
de Bono, Johann S. (The Institute of Cancer Research)
Cahill, Declan (The Royal Marsden NHS Foundation Trust)
Camacho, Niedzica (The Institute of Cancer Research)
Dennis, Nening M. (The Royal Marsden NHS Foundation Trust)
Dudderidge, Tim (University Hospital Southampton NHS Foundation Trust (Regne Unit))
Edwards, Sandra E. (The Institute of Cancer Research)
Fisher, Cyril (The Royal Marsden NHS Foundation Trust)
Foster, Christopher S. (University of Liverpool)
Ghori, Mohammed (Wellcome Trust Sanger Institute (Regne Unit))
Gill, Pelvender (University of Oxford)
Omberg, Larsson (Sage Bionetworks)
Gnanapragasam, Vincent J. (Academic Urology Group. Department of Surgery. University of Cambridge)
Gundem, Gunes (Memorial Sloan Kettering Cancer Center)
Hamdy, Freddie C. (University of Oxford. Oxford)
Hawkins, Steve (Cancer Research UK Cambridge Institute. University of Cambridge)
Hazell, Steve (The Royal Marsden NHS Foundation Trust)
Howat, William (Cambridge University Hospitals NHS Foundation Trust (Anglaterra))
Isaacs, William B. (Department of Urology. James Buchanan Brady Urological Institute. Johns Hopkins University School of Medicine)
Karaszi, Katalin (University of Oxford)
Kay, Jonathan D. (University College London)
Khoo, Vincent (The Royal Marsden NHS Foundation Trust)
Ferretti, Vimcent (Department of Biochemistry and Molecular Medicine. University of Montreal. Montreal)
Kote-Jarai, Zsofia (The Institute of Cancer Research)
Kremeyer, Barbara (Wellcome Trust Sanger Institute (Regne Unit))
Kumar, Pardeep (The Royal Marsden NHS Foundation Trust)
Lambert, Adam (University of Oxford)
Leongamornlert, Daniel A. (Wellcome Trust Sanger Institute (Regne Unit))
Livni, Naomi (The Royal Marsden NHS Foundation Trust)
Lu, Yong-Jie (Second Military Medical University)
Luxton, Hayley J. (University College London)
Marsden, Luke (University of Oxford)
Massie, Charlie E. (Cancer Research UK Cambridge Institute. University of Cambridge)
Sabarinathan, Radhakrishnan (Universitat Pompeu Fabra. Unitat de Recerca en Informàtica Biomèdica (GRIB))
Matthews, Lucy (The Institute of Cancer Research)
Mayer, Erik (Imperial College London)
McDermott, Ultan (Wellcome Trust Sanger Institute (Regne Unit))
Merson, Susan (The Institute of Cancer Research)
Neal, David E. (Cambridge University Hospitals NHS Foundation Trust (Anglaterra))
Ng, Anthony (The Chinese University of Hong Kong)
Nicol, David (The Royal Marsden NHS Foundation Trust)
Ogden, Christopher (The Royal Marsden NHS Foundation Trust)
Rowe, Edward W. (The Royal Marsden NHS Foundation Trust)
Shah, Nimish C. (Cambridge University Hospitals NHS Foundation Trust (Anglaterra))
Pich, Oriol (Institute for Research in Biomedicine (IRB Barcelona))
Thomas, Sarah (The Royal Marsden NHS Foundation Trust)
Thompson, Alan (The Royal Marsden NHS Foundation Trust)
Verrill, Clare (John Radcliffe Hospital (Oxford, Regne Unit))
Visakorpi, Tapio (Faculty of Medicine and Health Technology. Tampere University and Tays Cancer Center. Tampere University Hospital)
Warren, Anne Y. (Cambridge University Hospitals NHS Foundation Trust (Anglaterra))
Whitaker, Hayley C. (University College London)
Zhang, Hongwei (Second Military Medical University, Shanghai)
van As, Nicholas (The Royal Marsden NHS Foundation Trust)
Eeles, Rosalind (The Royal Marsden NHS Foundation Trust)
Abeshouse, Adam (Memorial Sloan Kettering Cancer Center)
Taylor-Weiner, Amaro (Broad Institute of MIT and Harvard)
Agrawal, Nishant (University of Chicago)
Akbani, Rehan (Department of Bioinformatics and Computational Biology and Department of Systems Biology. The University of Texas MD Anderson Cancer Center)
Al-Ahmadie, Hikmat (Memorial Sloan Kettering Cancer Center)
Albert, Matthew L. (Ontario Tumour Bank. Ontario Institute for Cancer Research)
Aldape, Kenneth (The University of Texas MD Anderson Cancer Center)
Ally, Adrian (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Appelbaum, Elisabeth L. (University College London)
Armenia, Joshua (Memorial Sloan Kettering Cancer Center)
Asa, Sylvia (University Health Network)
Auman, J. Todd (Department of Pathology and Laboratory Medicine. School of Medicine. University of North Carolina at Chapel Hill)
Demeulemeester, Jonas (University of Leuven)
Balasundaram, Miruna (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Balu, Saianand (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill)
Barnholtz-Sloan, Jill (Research Health Analytics and Informatics. University Hospitals Cleveland Medical Center)
Bathe, Oliver F. (Department of Surgery and Department of Oncology. University of Calgary)
Baylin, Stephen B. (University Hospital Southampton NHS Foundation Trust (Regne Unit))
Benz, Christopher (Buck Institute for Research on Aging)
Berchuck, Andrew (Duke University Medical Center)
Berrios, Mario (University of Southern California Norris Comprehensive Cancer Center)
Bigner, Darell (The Preston Robert Tisch Brain Tumor Center. Duke University Medical Center)
Birrer, Michael (Massachusetts General Hospital (Boston))
Tarabichi, Maxime (Wellcome Trust Sanger Institute (Regne Unit))
Bodenheimer, Tom (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill)
Boice, Lori (University of North Carolina at Chapel Hill)
Bootwalla, Moiz S. (University of Southern California Norris Comprehensive Cancer Center)
Bosenberg, Marcus (Department of Dermatology and Department of Pathology. Yale University)
Bowlby, Reanne (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Boyd, Jeffrey (Fox Chase Cancer Center)
Broaddus, Russell R. (Department of Pathology. The University of Texas MD Anderson Cancer Center)
Brock, Malcolm (Department of Surgery. Division of Thoracic Surgery. The Johns Hopkins University School of Medicine)
Brooks, Denise (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Bullman, Susan (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica). Department of Medical Oncology)
Roberts, Nicola Diane (Wellcome Trust Sanger Institute (Regne Unit))
Caesar-Johnson, Samantha J. (National Cancer Institute. National Institutes of Health)
Carey, Thomas E. (University of Michigan Comprehensive Cancer Center)
Carlsen, Rebecca (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Cerfolio, Robert (University of Alabama at Birmingham)
Chandan, Vishal S. (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Chen, Hsiao-Wei (Memorial Sloan Kettering Cancer Center)
Cherniack, Andrew D. (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica). Department of Medical Oncology)
Chien, Jeremy (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Cho, Juok (Broad Institute of MIT and Harvard)
Chuah, Eric (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Van Loo, Peter (University of Leuven)
Cibulskis, Carrie (Broad Institute of MIT and Harvard)
Cope, Leslie (Department of Oncology. The Johns Hopkins School of Medicine. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University)
Cordes, Matthew G. (Norfolk and Norwich University Hospital NHS Trust)
Curley, Erin (International Genomics Consortium)
Czerniak, Bogdan (Barking Havering and Redbridge University Hospital (Barking, Regne Unit))
Danilova, Ludmila (Department of Oncology. The Johns Hopkins School of Medicine. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University)
Davis, Ian J. (Department of Pediatrics and Department of Genetics. University of North Carolina at Chapel Hill)
Defreitas, Timothy (Broad Institute of MIT and Harvard)
Demchok, John A. (National Cancer Institute. National Institutes of Health)
Dhalla, Noreen (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Cortés-Ciriano, Isidro (Ludwig Center at Harvard Medical School)
Dhir, Rajiv (UPMC Shadyside (Pittsburgh, Estats Units d'Amèrica). Department of Pathology)
Doddapaneni, Harshavardhan (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
El-Naggar, Adel (Barking Havering and Redbridge University Hospital (Barking, Regne Unit))
Felau, Ina (National Cancer Institute. National Institutes of Health)
Ferguson, Martin L. (National Institutes of Health (Bethesda, Estats Units d'Amèrica). Center for Cancer Genomics)
Finocchiaro, Gaetano (Fondazione IRCCS Istituto Neurologico Carlo Besta (Milà, Itàlia))
Fong, Kwun M. (University of Queensland Thoracic Research Centre. The Prince Charles Hospital)
Frazer, Scott (Broad Institute of MIT and Harvard)
Friedman, William (Department of Neurosurgery. University of Florida)
Fronick, Catrina C. (Norfolk and Norwich University Hospital NHS Trust)
Urban, Lara (European Molecular Biology Laboratory (EMBL). Genome Biology Unit)
Fulton, L. A. (The McDonnell Genome Institute. Washington University)
Gabriel, Stacey B. (Broad Institute of MIT and Harvard)
Gao, Jianjiong (Memorial Sloan Kettering Cancer Center)
Gehlenborg, Nils (Harvard Medical School. Center for Biomedical Informatics)
Gershenwald, Jeffrey E. (Department of Surgical Oncology. The University of Texas MD Anderson Cancer Center)
Ghossein, Ronald (Memorial Sloan Kettering Cancer Center. Department of Pathology)
Giama, Nasra H. (Mayo Clinic (Rochester, Estats Units d'Amèrica). Division of Gastroenterology and Hepatology)
Gibbs, Richard A. (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Gomez, Carmen (Sylvester Comprehensive Cancer Center. University of Miami)
Govindan, Ramaswamy (Alvin J. Siteman Cancer Center. Washington University School of Medicine)
Zhu, Bin (Division of Cancer Epidemiology and Genetics. National Cancer Institute. National Institutes of Health)
Hayes, D. Neil (University of Tennessee Health Science Center for Cancer Research)
Hegde, Apurva M. (Department of Bioinformatics and Computational Biology and Department of Systems Biology. The University of Texas MD Anderson Cancer Center)
Heiman, David I. (Broad Institute of MIT and Harvard)
Heins, Zachary (Memorial Sloan Kettering Cancer Center)
Hepperla, Austin J. (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill)
Holbrook, Andrea (University of Southern California Norris Comprehensive Cancer Center)
Holt, Robert A. (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Hoyle, Alan P. (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill)
Hruban, Ralph H. (Department of Oncology. The Johns Hopkins School of Medicine. The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University)
Hu, Jianhong (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Pitkänen, Esa (European Molecular Biology Laboratory (EMBL). Genome Biology Unit)
Huang, Mei (University of North Carolina at Chapel Hill)
Huntsman, David G. (Centre for Translational and Applied Genomics. British Columbia Cancer Agency)
Huse, Jason (Memorial Sloan Kettering Cancer Center)
Iacobuzio-Donahue, Christine A. (Memorial Sloan Kettering Cancer Center. Department of Pathology)
Ittmann, Michael (Michael E. DeBakey Veterans Affairs Medical Center)
Jayaseelan, Joy C. (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Jefferys, Stuart R. (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill)
Jones, Corbin D. (Carolina Center for Genome Sciences. University of North Carolina at Chapel Hill)
Jones, Steven J. M. (Canada's Michael Smith Genome Sciences Centre. BC Cancer Agency)
Juhl, Hartmut (Indivumed)
Li, Yilong (Wellcome Trust Sanger Institute (Regne Unit))
Kang, Koo Jeong (Division of Hepatobiliary and Pancreatic Surgery. Department of Surgery. School of Medicine. Keimyung University Dong-san Medical Center)
Karlan, Beth (Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute. Cedars-Sinai Medical Center)
Kasaian, Katayoon (Canada's Michael Smith Genome Sciences Centre. BC Cancer Agency)
Kebebew, Electron (Endocrine Oncology Branch. Center for Cancer Research. National Cancer Institute. National Institutes of Health)
Kim, Hark Kyun (National Cancer Center)
Korchina, Viktoriya (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Kundra, Ritika (Memorial Sloan Kettering Cancer Center)
Lai, Phillip H. (University of Southern California Norris Comprehensive Cancer Center)
Lander, Eric (Broad Institute of MIT and Harvard)
Le, Xuan (ILSbio. LLC Biobank)
Saini, Natalie (Genome Integrity and Structural Biology Laboratory. National Institute of Environmental Health Sciences (NIEHS))
Lee, Donghoon (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Levine, Douglas A. (Gynecologic Oncology. NYU Laura and Isaac Perlmutter Cancer Center. New York University)
Lewis, Lora (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Ley, Tim (Division of Oncology. Stem Cell Biology Section. Washington University School of Medicine)
Li, Haiyan Irene (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Lin, Pei (Broad Institute of MIT and Harvard)
Linehan, William Marston (Urologic Oncology Branch. Center for Cancer Research. National Cancer Institute. National Institutes of Health)
Liu, Fei-Fei (University of Toronto)
Lu, Yiling (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education). Peking University Cancer Hospital & Institute)
Lype, Lisa (Institute for Systems Biology)
Klimczak, Leszek J. (Integrative Bioinformatics Support Group. National Institute of Environmental Health Sciences (NIEHS))
Ma, Yussanne (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Maglinte, Dennis T. (Center for Personalized Medicine. Department of Pathology and Laboratory Medicine. Children's Hospital Los Angeles)
Mardis, Elaine R. (Institute for Genomic Medicine. Nationwide Children's Hospital)
Marks, Jeffrey (Department of Surgery. Duke University)
Marra, Marco A. (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Matthew, Thomas J. (University of California Santa Cruz)
Mayo, Michael (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
McCune, Karen (Department of Obstetrics. Gynecology and Reproductive Services. University of California San Francisco)
Meier, Samuel R. (Broad Institute of MIT and Harvard)
Meng, Shaowu (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill)
Weischenfeldt, Joachim (Finsen Laboratory and Biotech Research & Innovation Centre (BRIC). University of Copenhagen)
Mieczkowski, Piotr A. (Department of Genetics. University of North Carolina at Chapel Hill)
Mikkelsen, Tom (Department of Neurology and Department of Neurosurgery. Henry Ford Hospital)
Miller, Christopher A. (The McDonnell Genome Institute. Washington University)
Mills, Gordon (Knight Cancer Institute. Oregon Health & Science University)
Moore, Richard A. (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Morrison, Carl (Department of Pathology. Roswell Park Cancer Institute)
Mose, Lisle E. (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill)
Moser, C. D. (Mayo Clinic (Rochester, Estats Units d'Amèrica). Division of Gastroenterology and Hepatology)
Mungall, Andrew J. (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Mungall, Karen (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Sidiropoulos, Nikos (Finsen Laboratory and Biotech Research & Innovation Centre (BRIC). University of Copenhagen)
Mutch, David (Department of Obstetrics and Gynecology. Division of Gynecologic Oncology. Washington University School of Medicine)
Muzny, Donna M. (Department of Palliative. Rehabilitation and Integrative Medicine. The University of Texas MD Anderson Cancer Center)
Myers, Jerome (Penrose St Francis Health Services)
Newton, Yulia (University of California Santa Cruz)
Noble, Michael S. (Broad Institute of MIT and Harvard)
O'Donnell, Peter (The University of Chicago)
O'Neill, Brian Patrick (Mayo Clinic Florida (Jacksonville, Estats Units d'Amèrica). Department of Neurology)
Ochoa, Angelica (Memorial Sloan Kettering Cancer Center)
Park, Ji Wan (Center for Liver Cancer. Research Institute and Hospital. National Cancer Center)
Parker, Joel S. (Department of Genetics and Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill)
Alexandrov, Ludmil B. (Wellcome Trust Sanger Institute (Regne Unit))
Pass, Harvey (NYU Langone Medical Center)
Pastore, Alessandro (Memorial Sloan Kettering Cancer Center)
Pennell, Nathan A. (Cleveland Clinic. Department of Hematology and Medical Oncology)
Perou, Charles M. (Department of Genetics. Department of Pathology and Laboratory Medicine. School of Medicine. University of North Carolina at Chapel Hill)
Petrelli, Nicholas (Helen F. Graham Cancer Center at Christiana Care Health Systems)
Potapova, Olga (Cureline)
Rader, Janet S. (Medical College of Wisconsin)
Ramalingam, Suresh (Hematology and Medical Oncology. Winship Cancer Institute of Emory University)
Rathmell, W. Kimryn (Vanderbilt Ingram Cancer Center. Vanderbilt University)
Reuter, Victor (Memorial Sloan Kettering Cancer Center. Department of Pathology)
Rabionet, Raquel (Universitat de Barcelona. Institut de Biomedicina)
Reynolds, Sheila M. (Institute for Systems Biology)
Ringel, Matthew (Ohio State University College of Medicine and Arthur G. James Comprehensive Cancer Center)
Roach, Jeffrey (Research Computing Center. University of North Carolina at Chapel Hill)
Roberts, Lewis R. (Mayo Clinic (Rochester, Estats Units d'Amèrica). Division of Gastroenterology and Hepatology)
Robertson, A. Gordon (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Sadeghi, Sara (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Saller, Charles (Analytical Biological Services)
Sanchez-Vega, Francisco (Memorial Sloan Kettering Cancer Center)
Schadendorf, Dirk (University Hospital Essen (Alemanya))
Schein, Jacqueline E. (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Escaramis, Georgia (Universitat de Girona. Grup de Recerca en Estadística, Econometria i Salut)
Schmidt, Heather K. (The McDonnell Genome Institute. Washington University)
Schultz, Nikolaus (Memorial Sloan Kettering Cancer Center)
Seethala, Raja (University of Pittsburgh)
Senbabaoglu, Yasin (Memorial Sloan Kettering Cancer Center)
Shelton, Troy (International Genomics Consortium)
Shi, Yan (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill)
Shih, Juliann (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica). Department of Medical Oncology)
Shmulevich, Ilya (Institute for Systems Biology)
Shriver, Craig (Murtha Cancer Center. Walter Reed National Military Medical Center)
Signoretti, Sabina (Harvard Medical School)
Bosio, Mattia (Universitat Pompeu Fabra)
Simons, Janae V. (Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill)
Singer, Samuel (Memorial Sloan Kettering Cancer Center)
Sipahimalani, Payal (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Skelly, Tara J. (Department of Genetics. University of North Carolina at Chapel Hill)
Smith-McCune, Karen (Department of Obstetrics. Gynecology and Reproductive Services. University of California San Francisco)
Socci, Nicholas D. (Memorial Sloan Kettering Cancer Center)
Soloway, Matthew G. (Department of Genetics and Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill)
Sood, Anil K. (Department of Gynecologic Oncology and Reproductive Medicine. and Center for RNA Interference and Non-Coding RNA. The University of Texas MD Anderson Cancer Center)
Tam, Angela (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Tan, Donghui (Department of Genetics. University of North Carolina at Chapel Hill)
Holik, Aliaksei Z. (Centre de Regulació Genòmica)
Tarnuzzer, Roy (National Cancer Institute. National Institutes of Health)
Thiessen, Nina (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Thompson, R. Houston (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Thorne, Leigh B. (University of North Carolina at Chapel Hill)
Tsao, Ming (University Health Network)
Umbricht, Christopher (Department of Surgery. Johns Hopkins University School of Medicine)
Van Den Berg, David J. (University of Southern California Norris Comprehensive Cancer Center)
Van Meir, Erwin G. (Department of Neurosurgery. Department of Hematology and Department of Medical Oncology. Winship Cancer Institute and School of Medicine. Emory University)
Veluvolu, Umadevi (Department of Genetics. University of North Carolina at Chapel Hill)
Voet, Douglas (Broad Institute of MIT and Harvard)
Susak, Hana (Universitat Pompeu Fabra)
Wang, Linghua (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Weinberger, Paul (Georgia Regents University Cancer Center)
Weisenberger, Daniel J. (University of Southern California Norris Comprehensive Cancer Center)
Wigle, Dennis (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Wilkerson, Matthew D. (Department of Genetics. University of North Carolina at Chapel Hill)
Wilson, Richard K. (Institute for Genomic Medicine. Nationwide Children's Hospital)
Winterhoff, Boris J. N. (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Wiznerowicz, Maciej (Poznan University of Medical Sciences)
Wong, Tina (Canada's Michael Smith Genome Sciences Center. BC Cancer Agency)
Wong, Wing Hing (Edison Family Center for Genome Sciences and Systems Biology. Washington University)
Prasad, Aparna (Universitat Pompeu Fabra)
Xi, Liu (Baylor College of Medicine (Houston, Estats Units d'Amèrica). Human Genome Sequencing Center)
Yau, Christina (Buck Institute for Research on Aging)
Zhang, Hailei (Broad Institute of MIT and Harvard, Cambridge)
Zhang, Hongxin (Memorial Sloan Kettering Cancer Center)
Zhang, Junjun (National Cancer Institute. National Institutes of Health)
Erkek, Serap (European Molecular Biology Laboratory (EMBL). Genome Biology Unit)

Fecha:	2020
Resumen:	Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation; analyses timings and patterns of tumour evolution; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity; and evaluates a range of more-specialized features of cancer genomes.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	Nature, Vol. 578 (February 2020) , p. 82-93, ISSN 1476-4687

DOI: 10.1038/s41586-020-1969-6
PMID: 32025007

50 p, 22.6 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias > Institut Català de Paleontologia Miquel Crusafont (ICP)
Artículos > Artículos de investigación
Artículos > Artículos publicados