Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome : A MAGNIMS multicentre study
Hagens, M. H. J. (Department of Neurology. MS Center Amsterdam. VU University Medical Center)
Burggraaff, Jessica (Department of Neurology. MS Center Amsterdam. VU University Medical Center)
Kilsdonk, I. D. (Department of Radiology and Nuclear Medicine. Onze Lieve Vrouwen Gasthuis)
Ruggieri, Serena (San Camillo Forlanini Hospital)
Collorone, S. (NMR Research Unit. Queen Square Multiple Sclerosis Centre. UCL Institute of Neurology)
Cortese, R. (Department of Basic Medical Sciences. Neurosciences and Sense Organs. University of Bari)
Cawley, Niamh (NMR Research Unit. Queen Square Multiple Sclerosis Centre. UCL Institute of Neurology)
Sbardella, E. (Department of Neurology and Psychiatry. Sapienza University of Rome)
Andelova, M. (University Hospital Basel (Basilea, Suïssa))
Amann, Michael (University Hospital Basel (Basilea, Suïssa))
Lieb, J. M. (University Hospital Basel (Basilea, Suïssa))
Pantano, P. (Istituto Neurologico Mediterraneo. Neuromed)
Lissenberg-Witte, B. I. (Department of Epidemiology and Biostatistics. VU University Medical Centre)
Killestein, Joep (Department of Neurology. MS Center Amsterdam. VU University Medical Center)
Oreja-Guevara, Celia (Hospital Clínico San Carlos (Madrid))
Wuerfel, J. (University Hospital Basel (Basilea, Suïssa))
Ciccarelli, Olga (NMR Research Unit. Queen Square Multiple Sclerosis Centre. UCL Institute of Neurology)
Gasperini, C. (San Camillo Forlanini Hospital)
Lukas, Cédric (Department of Diagnostic and Interventional Radiology and Nuclear Medicine. St. Josef Hospital. Ruhr University)
Rovira, A. (Hospital Universitari Vall d'Hebron)
Barkhof, Frederik (UCL Institute of Neurology (Regne Unit))
Wattjes, M. P. (Department of Radiology and Nuclear Medicine. MS Center Amsterdam. VU University Medical Center)
Universitat Autònoma de Barcelona

Data:	2019
Resum:	Background: Compared to 1. 5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. Objectives: The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. Methods: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort. All subjects received baseline 1. 5 and 3 T brain and spinal cord MRI. Patients also received follow-up brain MRI at 3-6 months. Four experienced neuroradiologists and four less-experienced raters scored the number of lesions per anatomical region and determined dissemination in space and time (McDonald 2010). Results: In controls, the mean number of lesions per rater was 0. 16 at 1. 5 T and 0. 38 at 3 T (p = 0. 005). For patients, this was 4. 18 and 4. 40, respectively (p = 0. 657). Inter-rater agreement on involvement per anatomical region and dissemination in space and time was moderate to good for both field strengths. 3 T slightly improved agreement between experienced raters, but slightly decreased agreement between less-experienced raters. Conclusion: Overall, the interobserver agreement was moderate to good. 3 T appears to improve the reading for experienced readers, underlining the benefit of additional training.
Nota:	The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This research has been supported by a programme grant (14-358e) from the Dutch MS Research Foundation (Voorschoten, The Netherlands). The study in London was supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Multiple sclerosis ; Clinically isolated syndrome ; Magnetic resonance imaging ; Interobserver variation ; Multicentre study
Publicat a:	Multiple sclerosis, Vol. 25 Núm. 3 (january 2019) , p. 352-360, ISSN 1477-0970

DOI: 10.1177/1352458517751647
PMID: 29327668

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