Web of Science: 4 citations, Scopus: 2 citations, Google Scholar: citations,
The vertebrate Aqp14 water channel is a neuropeptide-regulated polytransporter
Chauvigné, François (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Yilmaz, Ozlem (University of Bergen. Department of Biological Sciences)
Ferré, Alba (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Fjelldal, Per Gunnar (Matre Aquaculture Research Station)
Finn, Roderick Nigel (University of Bergen. Department of Biological Sciences)
Cerdà, Joan (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")

Date: 2019
Abstract: Water channels (aquaporins) were originally discovered in mammals with fourteen subfamilies now identified (AQP0-13). Here we show that a functional Aqp14 subfamily phylogenetically related to AQP4-type channels exists in all vertebrate lineages except hagfishes and eutherian mammals. In contrast to the water-selective classical aquaporins, which have four aromatic-arginine constriction residues, Aqp14 proteins present five non-aromatic constriction residues and facilitate the permeation of water, urea, ammonia, HO and glycerol. Immunocytochemical assays suggest that Aqp14 channels play important osmoregulatory roles in piscine seawater adaptation. Our data indicate that Aqp14 intracellular trafficking is tightly regulated by the vasotocinergic/isotocinergic neuropeptide and receptor systems, whereby protein kinase C and A transduction pathways phosphorylate highly conserved C-terminal residues to control channel plasma membrane insertion. The neuropeptide regulation of Aqp14 channels thus predates the vasotocin/vasopressin regulation of AQP2-5-6 orthologs observed in tetrapods. These findings demonstrate that vertebrate Aqp14 channels represent an ancient subfamily of neuropeptide-regulated polytransporters.
Note: Número d'acord de subvenció MINECO/AGL2016-76802-R
Note: Número d'acord de subvenció MINECO/RYC-2015-17103
Note: Número d'acord de subvenció MINECO/BES-2014-068745
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Evolutionary biology ; Ichthyology ; Molecular biology
Published in: Communications Biology, Vol. 2 (2019) , art. 462, ISSN 2399-3642

DOI: 10.1038/s42003-019-0713-y
PMID: 31840107


13 p, 3.9 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles

 Record created 2020-06-03, last modified 2020-12-10



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