Interplay between ncRNAs and cellular communication : A proposal for understanding cell-specific signaling pathways
Ramón y Cajal, Santiago (Centro de Investigación Biomédica en Red de Cáncer)
Segura, M. F. (Hospital Universitari Vall d'Hebron)
Hümmer, Stefan (Centro de Investigación Biomédica en Red de Cáncer)
Universitat Autònoma de Barcelona

Data:	2019
Resum:	Intercellular communication is essential for the development of specialized cells, tissues, and organs and is critical in a variety of diseases including cancer. Current knowledge states that different cell types communicate by ligand-receptor interactions: hormones, growth factors, and cytokines are released into the extracellular space and act on receptors, which are often expressed in a cell-type-specific manner. Non-coding RNAs (ncRNAs) are emerging as newly identified communicating factors in both physiological and pathological states. This class of RNA encompasses microRNAs (miRNAs, well-studied post-transcriptional regulators of gene expression), long non-coding RNAs (lncRNAs) and other ncRNAs. lncRNAs are diverse in length, sequence, and structure (linear or circular), and their functions are described as transcriptional regulation, induction of epigenetic changes and even direct regulation of protein activity. They have also been reported to act as miRNA sponges, interacting with miRNA and modulating its availability to endogenous mRNA targets. Importantly, lncRNAs may have a cell-type-specific expression pattern. In this paper, we propose that lncRNA-miRNA interactions, analogous to receptor-ligand interactions, are responsible for cell-type-specific outcomes. Specific binding of miRNAs to lncRNAs may drive cell-type-specific signaling cascades and modulate biochemical feedback loops that ultimately determine cell identity and response to stress factors.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1799 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1131 Instituto de Salud Carlos III CPII16-00006 Instituto de Salud Carlos III PI17-00564
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cancer ; Cellular communication ; Cell signaling ; Long non-coding RNA ; Microrna ; Epigenetics
Publicat a:	Frontiers in genetics, Vol. 10 Núm. APR (2019) , p. 281, ISSN 1664-8021

DOI: 10.3389/fgene.2019.00281
PMID: 31001323

11 p, 2.1 MB

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